ArticleNeuroImage. Clinical2013
Cerebral magnetic resonance elastography in supranuclear palsy and idiopathic Parkinson's disease.
Article in NeuroImage. Clinical, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 97 citations in OpenAlex.
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- Pulsatile Brain Motion as a Marker of Brain Aging and Dementia: Insights from 3D q-aMRI.medRxiv : the preprint server for health sciences · 2025Article
- MR elastography datasets including phantom, liver, and brain.Scientific data · 2025Article
- Shear Wave MR Elastography of the Orbit: Preliminary Findings.Diagnostics (Basel, Switzerland) · 2025Article
- Advanced Magnetic Resonance Imaging for Early Diagnosis and Monitoring of Movement Disorders.Brain sciences · 2025Review
- MRI-based whole-brain elastography and volumetric measurements to predict brain age.Biology methods & protocols · 2025Article
- The Networking Brain: How Extracellular Matrix, Cellular Networks, and Vasculature Shape the In Vivo Mechanical Properties of the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Feasibility of assessing non-invasive intracranial compliance using FSI simulation-based and MR elastography-based brain stiffness.Scientific reports · 2024Article
- Cortical matrix remodeling as a hallmark of relapsing-remitting neuroinflammation in MR elastography and quantitative MRI.Acta neuropathologica · 2024Article
- The contributions of relative brain viscosity to brain function and health.Brain communications · 2024Review
- Preoperative Magnetic Resonance Elastography (MRE) of Skull Base Tumours: A Review.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Vascular determinants of hippocampal viscoelastic properties in healthy adults across the lifespan.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Viscoelastic Property of the Brain Assessed With Magnetic Resonance Elastography and Its Association With Glymphatic System in Neurologically Normal Individuals.Korean journal of radiology · 2023Article
- Reverberant magnetic resonance elastographic imaging using a single mechanical driver.Physics in medicine and biology · 2023Article
- Article
- Evaluation of cerebral cortex viscoelastic property estimation with nonlinear inversion magnetic resonance elastography.Physics in medicine and biology · 2022Article
- Design, Construction, and Implementation of a Magnetic Resonance Elastography Actuator for Research Purposes.Current protocols · 2022Article
- The emerging roles of piezo1 channels in animal models of multiple sclerosis.Frontiers in immunology · 2022Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Detection and discrimination of neurodegenerative Parkinson syndromes are challenging clinical tasks and the use of standard T1- and T2-weighted cerebral magnetic resonance (MR) imaging is limited to exclude symptomatic Parkinsonism. We used a quantitative structural MR-based technique, MR-elastography (MRE), to assess viscoelastic properties of the brain, providing insights into altered tissue architecture in neurodegenerative diseases on a macroscopic level. We measured single-slice multifrequency MRE (MMRE) and three-dimensional MRE (3DMRE) in two neurodegenerative disorders with overlapping clinical presentation but different neuropathology - progressive supranuclear palsy (PSP: N = 16) and idiopathic Parkinson's disease (PD: N = 18) as well as in controls (N = 18). In PSP, both MMRE (Δμ = - 28.8%, Δα = - 4.9%) and 3DMRE (Δ|G*|: - 10.6%, Δφ: - 34.6%) were significantly reduced compared to controls, with a pronounced reduction within the lentiform nucleus (Δμ = - 34.6%, Δα = - 8.1%; Δ|G*|: - 7.8%, Δφ: - 44.8%). MRE in PD showed a comparable pattern, but overall reduction in brain elasticity was less severe reaching significance only in the lentiform nucleus (Δμ n.s., Δα = - 7.4%; Δ|G*|: - 6.9%, Δφ: n.s.). Beyond that, patients showed a close negative correlation between MRE constants and clinical severity. Our data indicate that brain viscoelasticity in PSP and PD is differently affected by the underlying neurodegeneration; whereas in PSP all MRE constants are reduced and changes in brain softness (reduced μ and |G*|) predominate those of viscosity (α and φ) in PD.
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