ReviewInternational journal of burns and trauma2013
Biochemical and biomechanical characterization of porcine small intestinal submucosa (SIS): a mini review.
Review in International journal of burns and trauma, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Porcine Small Intestinal Submucosa Extracellular Matrix: A Meta-Analysis of Composition, Processing Techniques, and Biomedical Applications.International journal of molecular sciences · 2025Pooled it
- Acellular Scaffolds as Innovative Biomaterial Platforms for the Management of Diabetic Wounds.Tissue engineering and regenerative medicine · 2021Pooled it
- Reconstruction of an orbital fracture in a mare using a 3D-printed patient-specific implant.Veterinary surgery : VS · 2026Article
- Histopathological Evaluation of Bioactive Glass Wound Sites in a Swine Model.Bioengineering (Basel, Switzerland) · 2026Article
- Role of the small intestinal submucosa-extracellular matrix grafts powder on regeneration of full-thickness wound in skin of rabbits.Open veterinary journal · 2026Article
- Effects of graphene oxide incorporationRSC advances · 2026Article
- Use of porcine small intestinal submucosa for reconstruction of a soft palate defect following marginal resection of a melanoma in a dog.The Journal of small animal practice · 2026Article
- Anti-Fibrotic Properties of a Decellularized Extracellular Matrix Scaffold from Porcine Small Intestinal Submucosa in Normal Human and Keloid Fibroblasts.International journal of molecular sciences · 2025Article
- Biomimetic, Suturable, and Extensible Electrospun Scaffolds for Lower Urinary Tract Surgical Reconstruction.Advanced healthcare materials · 2025Article
- Rabbit Corneal Wound Treatment Using Small Intestinal Submucosa (SIS) and Platelet Rich Plasma (PRP) Scaffold.Archives of Razi Institute · 2025Article
- Extracellular matrix-inspired biomaterials for wound healing.Molecular biology reports · 2024Review
- Reinforcing decellularized small intestine submucosa with cellulose acetate nanofibrous and silver nanoparticles as a scaffold for wound healing applications.Molecular biology reports · 2024Article
- Manufacture and evaluation of nano-silver-poly-DL-lactide-co-caprolactone-small intestinal submucosa biological mesh in abdominal wall reconstruction.Annals of translational medicine · 2024Article
- Varying Properties of Extracellular Matrix Grafts Impact Their Durability and Cell Attachment and Proliferation in anJournal of tissue engineering and regenerative medicine · 2024Article
- Preliminary in-silico analysis of vascular graft implantation configuration and surface modification.Scientific reports · 2023Article
- Updates on Recent Clinical Assessment of Commercial Chronic Wound Care Products.Advanced healthcare materials · 2023Review
- Vertebrate and Invertebrate Animal and New In Vitro Models for StudyingPathogens (Basel, Switzerland) · 2023Review
- Degassing a Decellularized Scaffold Enhances Wound Healing and Reduces Fibrosis during Tracheal Defect Reconstruction: A Preliminary Animal Study.Journal of functional biomaterials · 2023Article
- Skin substitutes as treatment for chronic wounds: current and future directions.Frontiers in medicine · 2023Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porcine small intestinal submucosa (SIS [Oasis(®)]) is an acellular, biological extracellular matrix (ECM) that has been found to significantly improve the healing of difficult-to-heal or chronic wounds in humans. Like dermal ECM, SIS contains collagen, elastin, glycosaminoglycans, proteoglycans, and growth factors that play important roles in healing. Preclinical studies have shown that numerous cell types attach to SIS, proliferate and migrate into the matrix, and differentiate. In addition, SIS can reduce the activity of matrix metalloproteinases (MMPs)-endogenous proteolytic enzymes whose levels and activities are increased in chronic wounds. Compared to the original single-layer SIS, multi-layer SIS has stronger mechanical properties and is more slowly degraded in wounds. Together, these SIS products provide flexibility in the selection of biologically-active ECMs that may be useful for the repair of diverse wound types.
Indexed as
Identifiers
24273692PMC3828736W135934010What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.