ArticleReproductive medicine and biology2013
Nuclear reprogramming of sperm and somatic nuclei in eggs and oocytes.
Article in Reproductive medicine and biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Setd2 overexpression rescues bivalent gene expression during SCNT-mediated ZGA.Protein & cell · 2025Article
- Sperm epigenetics and male infertility: unraveling the molecular puzzle.Human genomics · 2024Review
- Functions and Regulation of Endogenous Retrovirus Elements during Zygotic Genome Activation: Implications for Improving Somatic Cell Nuclear Transfer Efficiency.Biomolecules · 2021Review
- Insights into epigenetic patterns in mammalian early embryos.Protein & cell · 2021Review
- Differential Transcriptomes and Methylomes of Trophoblast Stem Cells From Naturally-Fertilized and Somatic Cell Nuclear-Transferred Embryos.Frontiers in cell and developmental biology · 2021Article
- Advance in the Role of Epigenetic Reprogramming in Somatic Cell Nuclear Transfer-Mediated Embryonic Development.Stem cells international · 2021Review
- Double sperm cloning (DSC) is a promising strategy in mammalian genetic engineering and stem cell research.Stem cell research & therapy · 2020Review
- Environmental Impact on Male (In)Fertility via Epigenetic Route.Journal of clinical medicine · 2020Review
- Generation of Transgenic Cloned Buffalo Embryos Harboring the EGFP Gene in the Y Chromosome Using CRISPR/Cas9-Mediated Targeted Integration.Frontiers in veterinary science · 2020Article
- KDM6A and KDM6B play contrasting roles in nuclear transfer embryos revealed by MERVL reporter system.EMBO reports · 2018Article
- Not just heads and tails: The complexity of the sperm epigenome.The Journal of biological chemistry · 2018Review
- Histone variant H3.3-mediated chromatin remodeling is essential for paternal genome activation in mouse preimplantation embryos.The Journal of biological chemistry · 2018Article
- Coexpression analysis identifies nuclear reprogramming barriers of somatic cell nuclear transfer embryos.Oncotarget · 2017Article
- Reprogramming towards totipotency is greatly facilitated by synergistic effects of small molecules.Biology open · 2017Article
- Immobilized pH in culture reveals an optimal condition for somatic cell reprogramming and differentiation of pluripotent stem cells.Reproductive medicine and biology · 2017Article
- Murine somatic cell nuclear transfer using reprogrammed donor cells expressing male germ cell-specific genes.The Journal of veterinary medical science · 2016Article
- Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing.Cell discovery · 2016Article
- Diversity and functional convergence of small noncoding RNAs in male germ cell differentiation and fertilization.RNA (New York, N.Y.) · 2015Article
- Cellular reprogramming for understanding and treating human disease.Frontiers in cell and developmental biology · 2014Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Eggs and oocytes have a prominent ability to reprogram sperm nuclei for ensuring embryonic development. The reprogramming activity that eggs/oocytes intrinsically have towards sperm is utilised to reprogram somatic nuclei injected into eggs/oocytes in nuclear transfer (NT) embryos. NT embryos of various species can give rise to cloned animals, demonstrating that eggs/oocytes can confer totipotency even to somatic nuclei. However, many studies indicate that reprogramming of somatic nuclei is not as efficient as that of sperm nuclei. In this review, we explain how and why sperm and somatic nuclei are differentially reprogrammed in eggs/oocytes. Recent studies have shown that sperm chromatin is epigenetically modified to be adequate for early embryonic development, while somatic nuclei do not have such modifications. Moreover, epigenetic memories encoded in sperm chromatin are transgenerationally inherited, implying unique roles of sperm. We also discuss whether somatic nuclei can be artificially modified to acquire sperm-like chromatin states in order to increase the efficiency of nuclear reprogramming.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.