SynthesisEnvironmental health perspectives2014
Exposure-response estimates for diesel engine exhaust and lung cancer mortality based on data from three occupational cohorts.
Synthesis in Environmental health perspectives, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 2 syntheses or guidelines pooled it, 158 citations in OpenAlex.
- Occupational Benzene Exposure and Lung Cancer in Human Studies: A Systematic Review and Meta-Analysis.Environmental health perspectives · 2024Pooled it
- Meta-Analysis of Cardiac Mortality in Three Cohorts of Carbon Black Production Workers.International journal of environmental research and public health · 2016Pooled it
- Lung function and self-rated symptoms in healthy volunteers after exposure to hydrotreated vegetable oil (HVO) exhaust with and without particles.Particle and fibre toxicology · 2022Trial
- Lung Cancer Screening and Prevention: Beyond Conventional Strategies in a Rapidly Changing Global Milieu.American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting · 2026Review
- Characterization of occupational exposure to air pollutants during asphalt milling and paving.Annals of work exposures and health · 2026Article
- Occupational Exposure to Diesel Particulate Matter in Western Australian Mining: A Retrospective Analysis and Challenges to Future Compliance.International journal of environmental research and public health · 2025Article
- Imogolite nanotube modifications impact pulmonary toxicity in mice: implications for safe and sustainable by design (SSbD).Journal of nanobiotechnology · 2025Article
- Advanced Diesel Powertrains for Underground Mining Mobile Equipment.Mining, metallurgy & exploration · 2025Article
- Pulmonary exposure to renewable diesel exhaust particles alters protein expression and toxicity profiles in bronchoalveolar lavage fluid and plasma of mice.Archives of toxicology · 2025Article
- Critical Issues in Assessing Occupational Exposure to Diesel Dust Exhaust.La Medicina del lavoro · 2024Article
- Narrative review of occupational exposures and noncommunicable diseases.Annals of work exposures and health · 2024Review
- Acute, controlled inhalation of thin graphene oxide nanosheets in humans with null cardiorespiratory effects.Nature nanotechnology · 2024Article
- Using particle dimensionality-based modeling to estimate lung carcinogenicity of 3D printer emissions.Journal of applied toxicology : JAT · 2024Article
- Methylated polycyclic aromatic hydrocarbons from household coal use across the life course and risk of lung cancer in a large cohort of 42,420 subjects in Xuanwei, China.Environment international · 2023Article
- What is next for occupational cancer epidemiology?Scandinavian journal of work, environment & health · 2022Article
- Underground emissions and miners' personal exposure to diesel and renewable diesel exhaust in a Swedish iron ore mine.International archives of occupational and environmental health · 2022Article
- Towards health-based nano reference values (HNRVs) for occupational exposure: Recommendations from an expert panel.NanoImpact · 2022Article
- Metabolomics and the Multi-Omics View of Cancer.Metabolites · 2022Review
- Article
- Assessment of occupational exposure to diesel particulate matter through evaluation of 1-nitropyrene and 1-aminopyrene in surface coal miners, India.Environmental monitoring and assessment · 2021Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundDiesel engine exhaust (DEE) has recently been classified as a known human carcinogen.
objectiveWe derived a meta-exposure-response curve (ERC) for DEE and lung cancer mortality and estimated lifetime excess risks (ELRs) of lung cancer mortality based on assumed occupational and environmental exposure scenarios.
methodsWe conducted a meta-regression of lung cancer mortality and cumulative exposure to elemental carbon (EC), a proxy measure of DEE, based on relative risk (RR) estimates reported by three large occupational cohort studies (including two studies of workers in the trucking industry and one study of miners). Based on the derived risk function, we calculated ELRs for several lifetime occupational and environmental exposure scenarios and also calculated the fractions of annual lung cancer deaths attributable to DEE.
resultsWe estimated a lnRR of 0.00098 (95% CI: 0.00055, 0.0014) for lung cancer mortality with each 1-μg/m3-year increase in cumulative EC based on a linear meta-regression model. Corresponding lnRRs for the individual studies ranged from 0.00061 to 0.0012. Estimated numbers of excess lung cancer deaths through 80 years of age for lifetime occupational exposures of 1, 10, and 25 μg/m3 EC were 17, 200, and 689 per 10,000, respectively. For lifetime environmental exposure to 0.8 μg/m3 EC, we estimated 21 excess lung cancer deaths per 10,000. Based on broad assumptions regarding past occupational and environmental exposures, we estimated that approximately 6% of annual lung cancer deaths may be due to DEE exposure.
conclusionsCombined data from three U.S. occupational cohort studies suggest that DEE at levels common in the workplace and in outdoor air appear to pose substantial excess lifetime risks of lung cancer, above the usually acceptable limits in the United States and Europe, which are generally set at 1/1,000 and 1/100,000 based on lifetime exposure for the occupational and general population, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.