ArticleDevelopmental psychobiology2014
Amygdala inactivation impairs eyeblink conditioning in developing rats.
Article in Developmental psychobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fear conditioning and extinction in obsessive-compulsive disorder: A systematic review.Neuroscience and biobehavioral reviews · 2021Pooled it
- Cerebellum-dependent associative learning is not impaired in a mouse model of neurofibromatosis type 1.Scientific reports · 2022Article
- Social buffering of plasma corticosterone and amygdala responses of young rats following exposure to periorbital shock: Implications for eyeblink conditioning development.Behavioral neuroscience · 2021Article
- Memory consolidation within the central amygdala is not necessary for modulation of cerebellar learning.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Central amygdala lesions inhibit pontine nuclei acoustic reactivity and retard delay eyeblink conditioning acquisition in adult rats.Learning & behavior · 2016Article
- Amygdala Modulation of Cerebellar Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Short-term, high-dose administration of corticosterone by injection facilitates trace eyeblink conditioning in young male rats.Behavioural brain research · 2016Article
- Hippocampal Non-Theta-Contingent Eyeblink Classical Conditioning: A Model System for Neurobiological Dysfunction.Frontiers in psychiatry · 2016Review
- Medial auditory thalamus is necessary for acquisition and retention of eyeblink conditioning to cochlear nucleus stimulation.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- Ontogeny of septohippocampal modulation of delay eyeblink conditioning.Developmental psychobiology · 2015Article
- Extinction, reacquisition, and rapid forgetting of eyeblink conditioning in developing rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The amygdala facilitates acquisition of eyeblink conditioning in adult animals by enhancing conditioned stimulus (CS) inputs to the cerebellum and the unconditioned response circuitry. Ontogenetic changes in amygdala modulation of eyeblink conditioning have not been investigated directly. We examined the effects of amygdala inactivation on the ontogeny of eyeblink conditioning and conditioned freezing in rat pups. Rat pups received bilateral infusions of saline or bupivacaine into the central nucleus of the amygdala before each of the first five training sessions, which consisted of paired CS-US trials on postnatal days (P) 17-19, P21-23, or P24-26. The final session consisted of CS-alone test trials to assess the effect of amygdala inactivation during training on conditioned freezing. Amygdala inactivation impaired acquisition of eyeblink conditioning in all of the age groups and impaired freezing to the context during the extinction test. The results indicate that the amygdala modulates cerebellar learning as soon as it begins to emerge ontogenetically.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.