ArticleInternational journal of geriatric psychiatry2014
The relationship between interleukin-1 receptor antagonist and cognitive function in older adults with bipolar disorder.
Article in International journal of geriatric psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 7 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Biofluid Biomarkers of Cognitive Functioning in Bipolar Disorder: A Systematic Review by the Targeting Cognition and Older-Age Bipolar Disorder ISBD Task Forces.Bipolar disorders · 2026Pooled it
- Association Between Inflammatory Markers and Cognitive Function in Adults With Bipolar Disorder: A Systematic Review.Acta psychiatrica Scandinavica · 2026Pooled it
- The association of blood biomarkers with cerebral white matter and myelin content in bipolar disorder: a systematic review.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2024Pooled it
- Neurotrophins, cytokines, oxidative stress mediators and mood state in bipolar disorder: systematic review and meta-analyses.The British journal of psychiatry : the journal of mental science · 2018Pooled it
- A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression.Molecular psychiatry · 2016Pooled it
- Peripheral blood brain-derived neurotrophic factor in bipolar disorder: a comprehensive systematic review and meta-analysis.Molecular psychiatry · 2016Pooled it
- Peripheral brain-derived neurotrophic factor (BDNF) as a biomarker in bipolar disorder: a meta-analysis of 52 studies.BMC medicine · 2015Pooled it
- Effects of proinflammatory cytokines and programmed cell death on cognitive domains in older age patients with bipolar disorder.Annals of general psychiatry · 2025Article
- Combination Therapy Against Mood and Anxiety Disorders: Association Between Efficacy and White Blood Cell Count.Neuropsychiatric disease and treatment · 2025Article
- Plasma and CSF biomarkers of aging and cognitive decline in Caribbean vervets.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Correlations between multimodal neuroimaging and peripheral inflammation in different subtypes and mood states of bipolar disorder: a systematic review.International journal of bipolar disorders · 2024Review
- Inflammatory Biomarkers, Cognitive Functioning, and Brain Imaging Abnormalities in Bipolar Disorder: A Systematic Review.Clinical neuropsychiatry · 2024Review
- Neurodevelopmental and Neuropsychiatric Disorders.Advances in neurobiology · 2024Review
- Monoclonal antibody precision therapy targeting inflammation for bipolar disorder: a narrative review.Therapeutic advances in psychopharmacology · 2024Review
- Cognition in Bipolar Disorder: An Update for Clinicians.Focus (American Psychiatric Publishing) · 2023Review
- The association between kidney function, cognitive function, and structural brain abnormalities in community-dwelling individuals aged 50+ is mediated by age and biomarkers of cardiovascular disease.Cardiovascular research · 2023Article
- Prognostic prediction of subjective cognitive decline in major depressive disorder based on immune biomarkers: a prospective observational study.BMC psychiatry · 2023Observational
- Impact of depressive disorders on clinical outcomes in patients with chronic heart failure.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2022Article
- A serum proteomic study of two case-control cohorts identifies novel biomarkers for bipolar disorder.Translational psychiatry · 2022Article
- Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis.Translational psychiatry · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveCognitive impairments are a feature of bipolar disorder (BD) and could be worsened by inflammatory cytokines. We determined whether (i) serum interleukin-1 receptor antagonist (IL-1RA) was increased in elderly BD subjects; (ii) whether IL-1RA was associated with worse neurocognitive function; and (iii) whether IL-1RA was associated with white matter integrity.
methodsTwenty-one euthymic BD patients (65 +/- 9 years) with serum available for IL-1RA measures by enzyme-linked immunoassays were compared with 26 similarly aged control participants. Four factor analysis-derived z-scores and a global z-score were obtained from a battery of 21 neurocognitive tests. Diffusion tensor images were used to obtain fractional anisotropy (FA), and an automated labeling pathway algorithm was used to obtain white matter hyperintensity burden.
resultsInterleukin-1 receptor antagonist was elevated in BD subjects compared with controls (439+/-326 pg/mL vs. 269+/-109 pg/mL; p = 0.004). Moreover, IL-1RA was inversely correlated with three cognitive function factors and global cognition (r = -0.37; p = 0.01). IL-1RA continued to correlate with global cognitive function even when covarying for either IL-6 or brain-derived neurotrophic factor. Although FA was lower in BD subjects (0.368 +/- 0.02 vs. 0.381 +/- 0.01; p = 0.02), IL-1RA was not associated with FA or white matter hyperintensity burden.
conclusionElevated serum levels of IL-1RA in BD subjects, even during euthymic states, were associated with worse cognitive function. This association was not explained by co-occurring increases in IL-6, by decreased brain-derived neurotrophic factor, nor by measures of white matter integrity. These cross-sectional findings support the possibility that the IL-1 family may contribute to cognitive impairments in BD.
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