ReviewJournal of molecular neuroscience : MN2014
The ascending mesolimbic cholinergic system--a specific division of the reticular activating system involved in the initiation of negative emotional states.
Review in Journal of molecular neuroscience : MN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Dysregulation of local inhibitory inputs onto laterodorsal tegmental nucleus cholinergic neurons drives depression-like behaviors in mice.Molecular psychiatry · 2026Article
- Humans correctly assign emotional valence of rat vocalizations.Frontiers in psychology · 2026Article
- Brain-Wide Patterns of CRF Receptor 1 Expression in the Transgenic CRFR1-Cre-2a-tdTom Rat.The Journal of comparative neurology · 2025Article
- From emotional arousal to executive action. Role of the prefrontal cortex.Brain structure & function · 2024Review
- Whole-Body Vibration Prevents Neuronal, Neurochemical, and Behavioral Effects of Morphine Withdrawal in a Rat Model.International journal of molecular sciences · 2023Article
- The bidirectional association of 24-h activity rhythms and sleep with depressive symptoms in middle-aged and elderly persons.Psychological medicine · 2023Article
- Water Drinking Behavior Associated with Aversive Arousal in Rats: An Integrative Approach.Brain sciences · 2022Review
- Temporal dynamics of affect in the brain: Evidence from human imaging and animal models.Neuroscience and biobehavioral reviews · 2022Review
- Brain-wide Mapping of Mono-synaptic Afferents to Different Cell Types in the Laterodorsal Tegmentum.Neuroscience bulletin · 2019Article
- Negative Affect-Associated USV Acoustic Characteristics Predict Future Excessive Alcohol Drinking and Alcohol Avoidance in Male P and NP Rats.Alcoholism, clinical and experimental research · 2017Article
- The Brainstem in Emotion: A Review.Frontiers in neuroanatomy · 2017Review
- Pharmacology of Ultrasonic Vocalizations in adult Rats: Significance, Call Classification and Neural Substrate.Current neuropharmacology · 2015Review
- The Innate Alarm System and Subliminal Threat Presentation in Posttraumatic Stress Disorder: Neuroimaging of the Midbrain and Cerebellum.Chronic stress (Thousand Oaks, Calif.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The review summarizes evidences from extensive studies suggesting that ascending mesolimbic cholinergic system (AMCS) that terminates in vast areas of forebrain and diencephalic limbic areas is responsible for specific generation of aversive arousal and aversive emotional state. This state is accompanied by emission of threatening and/or alarming vocalizations that served as a quantitative measure of the emotional response. The AMCS originates from the cholinergic neurons within the laterodorsal tegmental nucleus that have widespread and diffuse ascending connections. Activity of the AMCS induced by activation of the muscarinic cholinergic receptors in the terminal fields of this system, or by glutamate stimulation of neurons of the laterodorsal tegmental nucleus, brings about aversive state with alarming vocalizations. It is postulated that release of acetylcholine from the terminals of the AMCS in the vast areas of the forebrain and diencephalon serves as the initiator of the aversive emotional state with concomitant manifestations and alarming vocal signaling. It is concluded that the AMCS serves as a specific physiological, psychological, and social arousing and alarming system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.