ArticlePathology oncology research : POR2014
Down-regulation of ROBO2 expression in prostate cancers.
Article in Pathology oncology research : POR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Revealing the Drivers Underlying Distinct Evolutionary Trajectories in Lung Adenocarcinoma.bioRxiv : the preprint server for biology · 2025Article
- A new immune-related gene signature predicts the prognosis and immune escape of bladder cancer.Cancer biomarkers : section A of Disease markers · 2023Article
- ROBO1 protein expression is independently associated with biochemical recurrence in prostate cancer patients who underwent radical prostatectomy in Asian patients.Gland surgery · 2021Article
- HighExperimental biology and medicine (Maywood, N.J.) · 2021Article
- Alcohol Intake and Alcohol-SNP Interactions Associated with Prostate Cancer Aggressiveness.Journal of clinical medicine · 2021Article
- Article
- 'Multi-omic' data analysis using O-miner.Briefings in bioinformatics · 2019Article
- Article
- Intra-tumor heterogeneity in TP53 null High Grade Serous Ovarian Carcinoma progression.BMC cancer · 2015Article
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3 authors at 1 institution in 1 country.
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Abstract
Several lines of evidence exist that axon guidance genes are involved in cancer pathogenesis. Axon guidance genes ROBO1 and ROBO2 are candidate tumor suppressor genes (TSG). The aim of our study was to address whether ROBO1 and ROBO2 expressions are altered in prostate cancers (PCA). In this study, we analyzed ROBO1 and ROBO2 expressions in 107 PCAs. In the immunohistochemistry, loss of ROBO2 expression was identified in 66 % of PCAs and was significantly higher than that in normal cells (p < 0.001). By contrast, there was no significant difference of ROBO1 expression between normal and PCAs. Our results indicate that axon guidance protein ROBO2 is frequently lost in PCA and that ROBO2 might be involved in PCA pathogenesis as a candidate TSG.
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