ArticleEndocrine2014
Lifetime, untreated isolated GH deficiency due to a GH-releasing hormone receptor mutation has beneficial consequences on bone status in older individuals, and does not influence their abdominal aorta calcification.
Article in Endocrine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Clinical dermatoendocrinology: saving lives by looking at the skin.Archives of endocrinology and metabolism · 2025Review
- Skin assessment in congenital untreated isolated GH deficiency.Endocrine · 2024Article
- Function and form of the shoulder in congenital and untreated growth hormone deficiency.Endocrine · 2023Article
- The state of Sergipe contribution to GH research: from Souza Leite to Itabaianinha syndrome.Archives of endocrinology and metabolism · 2022Review
- Quantitative measures of the vascular and neural components of the retina in adult individuals with congenital and untreated growth hormone deficiency.International journal of retina and vitreous · 2022Article
- Skeletal disorders associated with the growth hormone-insulin-like growth factor 1 axis.Nature reviews. Endocrinology · 2022Review
- Disruption of the GHRH receptor and its impact on children and adults: The Itabaianinha syndrome.Reviews in endocrine & metabolic disorders · 2021Review
- Article
- Growth Hormone Deficiency: Health and Longevity.Endocrine reviews · 2019Review
- Walking and postural balance in adults with severe short stature due to isolated GH deficiency.Endocrine connections · 2019Article
- The visceral adiposity index is associated with insulin sensitivity and IGF-I levels in adults with growth hormone deficiency.Endocrine · 2017Article
- Incidence of morphometric vertebral fractures in adult patients with growth hormone deficiency.Endocrine · 2016Article
- Brazilian adult individuals with untreated isolated GH deficiency do not have accelerated subclinical atherosclerosis.Endocrine connections · 2016Article
- Older individuals heterozygous for a growth hormone-releasing hormone receptor gene mutation are shorter than normal subjects.Journal of human genetics · 2015Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The GH/IGF-I axis has essential roles in regulating bone and vascular status. The age-related decrease in GH secretion ("somatopause") may contribute to osteoporosis and atherosclerosis, commonly observed in the elderly. Adult-onset GH deficiency (GHD) has been reported to be associated with reduced bone mineral density (BMD), increased risk of fractures, and premature atherosclerosis. We have shown the young adult individuals with isolated GHD (IGHD) due to a homozygous for the c.57+1G>A GHRH receptor gene mutation have normal volumetric BMD (vBMD), and not develop premature atherosclerosis, despite adverse risk factor profile. However, the bone and vascular impact of lifetime GHD on the aging process remains unknown. We studied a group of ten older IGHD subjects (≥60 years) homozygous for the mutation, comparing them with 20 age- and gender-matched controls (CO). Areal BMD was measured, and vBMD was calculated at the lumbar spine and total hip. Vertebral fractures and abdominal aortic calcifications (expressed as calcium score) were also assessed. Areal BMD was lower in IGHD, but vBMD was similar in the two groups. The percent of fractured individuals was similar, but the mean number of fractures per individual was lower in IGHD than CO. Calcium score was similar in the two groups. A positive correlation was found between calcium score and number of fractures. Untreated lifetime IGHD has beneficial consequences on bone status and does not have a deleterious effect on abdominal aorta calcification.
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