ArticleEuropean archives of psychiatry and clinical neuroscience2014
Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders.
Article in European archives of psychiatry and clinical neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 77 citations in OpenAlex.
- Progression to Dementia in Very Late-Onset Schizophrenia-Like Psychosis Stratified by Alzheimer's Disease and Lewy Body Disease Biomarkers: A Retrospective Cohort Study.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Article
- High prevalence of tau pathologies in late-onset psychosis: A PET study.Molecular psychiatry · 2026Article
- Exploring the neuropathological basis of lateral ventricular enlargement in elderly patients with schizophrenia.Psychiatry and clinical neurosciences · 2026Article
- Contribution of comorbid pathologies to amyotrophic lateral sclerosis with cognitive or behavioral abnormalities.BMC neurology · 2025Article
- Systematized delusions in a patient with covert hepatic encephalopathy: A clinicopathological insight into prodromal dementia with Lewy bodies.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Validation of the neuropathological criteria of the fourth Consortium on dementia with Lewy Bodies in autopsy cases from psychiatric hospitals.Psychiatry and clinical neurosciences · 2025Article
- Diverse tau pathologies in late-life mood disorders revealed by PET and autopsy assays.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Morphological substrate of chronic schizophrenia in elderly patients: a clinicopathological study.Free neuropathology · 2025Article
- A case of argyrophilic grain disease with an initial clinical diagnosis of Parkinson's disease.Journal of neurology · 2024Article
- Pure argyrophilic grain disease revisited: independent effects on limbic, neocortical, and striato-pallido-nigral degeneration and the development of dementia in a series with a low to moderate Braak stage.Acta neuropathologica communications · 2024Article
- Amygdala granular fuzzy astrocytes are independently associated with both LATE neuropathologic change and argyrophilic grains: a study of Japanese series with a low to moderate Braak stage.Acta neuropathologica communications · 2023Article
- Argyrophilic grain disease is common in older adults and may be a risk factor for suicide: a study of Japanese forensic autopsy cases.Translational neurodegeneration · 2023Article
- Towards an understanding of the pathological basis of senile depression and incident dementia: Implications for treatment.Psychiatry and clinical neurosciences · 2022Review
- Recent Advances and Future Directions in Brain MR Imaging Studies in Schizophrenia: Toward Elucidating Brain Pathology and Developing Clinical Tools.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Article
- Characteristics of very late-onset schizophrenia-like psychosis as prodromal dementia with Lewy bodies: a cross-sectional study.Alzheimer's research & therapy · 2022Article
- Psychosis in Alzheimer disease - mechanisms, genetics and therapeutic opportunities.Nature reviews. Neurology · 2022Review
- Clinical Spectrum of Tauopathies.Frontiers in neurology · 2022Review
- Excess tau PET ligand retention in elderly patients with major depressive disorder.Molecular psychiatry · 2021Article
- Case Report: Usefulness of Biomarkers for Alzheimer's Disease in Two Cases With Very-Late-Onset Schizophrenia-Like Psychosis.Frontiers in psychiatry · 2021Article
- Hippocampal Sclerosis, Argyrophilic Grain Disease, and Primary Age-Related Tauopathy.Continuum (Minneapolis, Minn.) · 2019Review
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10 authors at 2 institutions in 1 country.
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Abstract
To study the relationship between neurodegenerative diseases including argyrophilic grain disease (AGD) and late-onset schizophrenia and delusional disorders (LOSD; onset ≥40 years of age), we pathologically examined 23 patients with LOSD, 71 age-matched normal controls, and 22 psychiatric disease controls (11 depression, six personality disorder, two bipolar disorders, and three neurotic disorders cases). In all LOSD cases (compared to age-matched normal controls), the frequencies of Lewy body disease (LBD), AGD, and corticobasal degeneration (CBD) were 26.1 % (11.3 %), 21.7 % (8.5 %), and 4.3 % (0.0 %), respectively. There was no case of pure Alzheimer's disease (AD). The total frequency of LBD, AGD, and CBD was significantly higher in LOSD cases than in normal controls. Argyrophilic grains were significantly more severe in LOSD than in controls, but were almost completely restricted to the limbic system and adjacent temporal cortex. In LOSD patients whose onset occurred at ≥65 years of age (versus age-matched normal controls), the frequencies of LBD and AGD were 36.4 % (19.4 %) and 36.4 % (8.3 %), respectively, and AGD was significantly more frequent in LOSD patients than in normal controls. In LOSD patients whose onset occurred at <65 years of age, the frequencies of LBD, AGD, and CBD were 16.7, 8.3, and 8.3 %, comparable to those of age-matched normal controls (10.2, 5.1, and 0.0 %). In all psychiatric cases, delusion was significantly more frequent in AGD cases than in cases bearing minimal AD pathology alone. Given these findings, LOSD patients may have heterogeneous pathological backgrounds, and AGD may be associated with the occurrence of LOSD especially after 65 years of age.
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