Trial reportEuropean radiology2014
Dose reduction in dynamic CT stress myocardial perfusion imaging: comparison of 80-kV/370-mAs and 100-kV/300-mAs protocols.
Trial report in European radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03324308 (The Safety, Feasibility and Accuracy of Dynamic Computed Tomography Myocardial Perfusion Imaging for Detection of Coronary Artery Disease), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Safety, Feasibility and Accuracy of Dynamic Computed Tomography Myocardial Perfusion Imaging for Detection of Coronary Artery Disease
Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with ¹⁵O-H₂O PET.European radiology · 2014Trial
- Super-Resolution Deep Learning Reconstruction Improves Image Quality of Dynamic Myocardial Computed Tomography Perfusion Imaging.Tomography (Ann Arbor, Mich.) · 2026Article
- Super-resolution deep learning reconstruction for improved quality of myocardial CT late enhancement.Japanese journal of radiology · 2025Article
- Test-retest reproducibility of absolute myocardial blood flow obtained using stress dynamic CT myocardial perfusion imaging.International journal of cardiology. Heart & vasculature · 2024Article
- Reproducibility of a single-volume dynamic CT myocardial blood flow measurement technique: validation in a swine model.European radiology experimental · 2024Article
- Dose Reduction of Dynamic Computed Tomography Myocardial Perfusion Imaging by Tube Voltage Change: Investigation in a Swine Model.Frontiers in cardiovascular medicine · 2022Article
- Low-dose CT perfusion with combined use of CTP and CTP-derived coronary CT angiography at 70 kVp: validation with invasive fractional flow reserve.European radiology · 2021Article
- PATIENT-SPECIFIC DOSE ESTIMATES IN DYNAMIC COMPUTED TOMOGRAPHY MYOCARDIAL PERFUSION EXAMINATION.Radiation protection dosimetry · 2021Article
- Dynamic CT Myocardial Perfusion Imaging in Patients without Obstructive Coronary Artery Disease: Quantification of Myocardial Blood Flow according to Varied Heart Rate Increments after Stress.Korean journal of radiology · 2021Article
- Cardiac CT perfusion and FFRCardiovascular diagnosis and therapy · 2020Review
- Clinical quantitative cardiac imaging for the assessment of myocardial ischaemia.Nature reviews. Cardiology · 2020Article
- Myocardial Coverage and Radiation Dose in Dynamic Myocardial Perfusion Imaging Using Third-Generation Dual-Source CT.Korean journal of radiology · 2020Article
- Imaging of coronary flow capacity: is there a role for dynamic CT perfusion imaging?European journal of nuclear medicine and molecular imaging · 2019Article
- CT myocardial perfusion imaging: ready for prime time?European radiology · 2018Article
- Myocardial Assessment with Cardiac CT: Ischemic Heart Disease and Beyond.Current cardiovascular imaging reports · 2018Review
- Myocardial blood flow quantification for evaluation of coronary artery disease by computed tomography.Cardiovascular diagnosis and therapy · 2017Review
- Temporal averaging for analysis of four-dimensional whole-heart computed tomography perfusion of the myocardium: proof-of-concept study.The international journal of cardiovascular imaging · 2017Article
- Static and dynamic assessment of myocardial perfusion by computed tomography.European heart journal. Cardiovascular Imaging · 2016Review
- Quantitative Myocardial Perfusion with Dynamic Contrast-Enhanced Imaging in MRI and CT: Theoretical Models and Current Implementation.BioMed research international · 2016Review
- Noninvasive physiologic assessment of coronary stenoses using cardiac CT.BioMed research international · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine the effect of reduced 80-kV tube voltage with increased 370-mAs tube current on radiation dose, image quality and estimated myocardial blood flow (MBF) of dynamic CT stress myocardial perfusion imaging (CTP) in patients with a normal body mass index (BMI) compared with a 100-kV and 300-mAs protocol.
methodsThirty patients with a normal BMI (<25 kg/m(2)) with known or suspected coronary artery disease underwent adenosine-stress dual-source dynamic CTP. Patients were randomised to 80-kV/370-mAs (n = 15) or 100-kV/300-mAs (n = 15) imaging. Maximal enhancement and noise of the left ventricular (LV) cavity, contrast-to-noise ratio (CNR) and MBF of the two groups were compared.
resultsImaging with 80-kV/370-mAs instead of 100-kV/300-mAs was associated with 40% lower radiation dose (mean dose-length product, 359 ± 66 vs 628 ± 112 mGy[Symbol: see text]cm; P < 0.001 ) with no significant difference in CNR (34.5 ± 13.4 vs 33.5 ± 10.4; P = 0.81) or MBF in non-ischaemic myocardium (0.95 ± 0.20 vs 0.99 ± 0.25 ml/min/g; P = 0.66). Studies obtained using 80-kV/370-mAs were associated with 30.9% higher maximal enhancement (804 ± 204 vs 614 ± 115 HU; P < 0.005), and 31.2% greater noise (22.7 ± 3.5 vs 17.4 ± 2.6; P < 0.001).
conclusionsDynamic CTP using 80-kV/370-mA instead of 100-kV/300-mAs allowed 40% dose reduction without compromising image quality or MBF. Tube voltage of 80-kV should be considered for individuals with a normal BMI. KEY POINTS: • CT stress perfusion imaging (CTP) is increasingly used to assess myocardial function. • Dynamic CTP is feasible at 80-kV in patients with normal BMI. • An 80-kV/370-mAs protocol allows 40% dose reduction compared with 100-kV/300-mAs. • Contrast-to-noise ratio and myocardial blood flow of the two protocols were comparable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.