ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
Differential expression profiling of microRNAs and their potential involvement in esophageal squamous cell carcinoma.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
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Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Clinical value of integrated-signature miRNAs in esophageal cancer.Cancer medicine · 2017Pooled it
- miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma.Oncotarget · 2016Pooled it
- Diagnostic value of microRNA-21 in the diagnosis of lung cancer: evidence from a meta-analysis involving 11 studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis.PloS one · 2014Pooled it
- Targeting Drp1 inhibits ESCC progression via the ROS-PGC1-α-Nrf1/2 pathway.Journal of translational medicine · 2025Article
- MicroRNAs: A novel signature in the metastasis of esophageal squamous cell carcinoma.World journal of gastroenterology · 2024Review
- Characterization of a five-microRNA signature as a prognostic biomarker for esophageal squamous cell carcinoma.Scientific reports · 2019Article
- Identifying the differentially expressed microRNAs in esophagus squamous cell carcinoma of Kazakh patients in Xinjiang.Oncology letters · 2019Article
- miR-451: A Novel Biomarker and Potential Therapeutic Target for Cancer.OncoTargets and therapy · 2019Review
- MicroRNA‑665 suppresses the growth and migration of ovarian cancer cells by targeting HOXA10.Molecular medicine reports · 2018Article
- Identification and verification of differentially expressed microRNAs and their target genes for the diagnosis of esophageal cancer.Oncology letters · 2018Article
- miRNA-429 Inhibits Astrocytoma Proliferation and Invasion by Targeting BMI1.Pathology oncology research : POR · 2017Article
- High expression of miR-16 and miR-451 predicating better prognosis in patients with gastric cancer.Journal of cancer research and clinical oncology · 2016Article
- MiR-451 inhibits proliferation of esophageal carcinoma cell line EC9706 by targeting CDKN2D and MAP3K1.World journal of gastroenterology · 2015Article
- Zinc finger A20 and NF-κB correlate with high-risk human papillomavirus of squamous cell carcinoma patients.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Article
- microRNA-195-Cdc42 axis acts as a prognostic factor of esophageal squamous cell carcinoma.International journal of clinical and experimental pathology · 2014Article
- Association of p53 expression with prognosis in patients with esophageal squamous cell carcinoma.International journal of clinical and experimental pathology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs are small, noncoding RNAs approximately 18-24 nucleotides in length that negatively regulate gene expression at the posttranscriptional and/or translational level by binding to complimentary sequences in the 3'-untranslated regions of target mRNAs. Growing evidence has indicated the important roles for different miRNA species in the development of different cancers. Therefore, miRNAs have the potential to become new biological markers for esophageal squamous cell carcinoma (ESCC) and to be applied in the diagnosis, prognosis, and targeted treatment of ESCC. In this study, we performed a miRNA microarray to analyze the miRNA expression profile in ESCC compared to normal tissues. Then, we made a preliminary analysis of the biological function for the most differentially expressed miRNAs and their potentially target genes regulated. Some microarray results were validated by performing quantitative RT-PCR. The study provided evidence that linked the biological role of miRNAs to ESCC and showed that miRNAs could undertake a variety of mechanisms. Additionally, we also found that altered miR-429 and miR-451 expression levels were associated with the occurrence of lymph node metastases and the differentiation status and TNM stage in ESCC. The study of miRNAs may lead to finding novel methods to diagnose, treat, and prevent ESCC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.