Evidence map›Paper›PMID 24270515›Full record

ArticleNature immunology2014

Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection.

Arby Abtin, Rohit Jain, Andrew J Mitchell, Ben Roediger, Anthony J Brzoska, Shweta Tikoo, Qiang Cheng, Lai Guan Ng, Lois L Cavanagh, Ulrich H von Andrian and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 157 papers.

0numbers the graph read from it
0cells of the map it votes in
157citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

157 citing papers in PubMed.

  1. Thromborepair: the tissue repair partner to thromboinflammation.Blood vessels, thrombosis & hemostasis · 2026
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  6. Acta pharmaceutica Sinica. B · 2026
    Article
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  8. Review
  9. Article
  10. Review
  11. Insights Into Stria Vascular Function, Stria Immunity, and Age-Related Hearing Loss.Journal of the Association for Research in Otolaryngology : JARO · 2025
    Review
  12. Article
  13. Article
  14. Intestinal CD4Nature communications · 2025
    Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review

97 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Arby Abtin1] The Centenary Institute, Newtown, New South Wales, Australia. [2].
Rohit Jain1] The Centenary Institute, Newtown, New South Wales, Australia. [2].ORCID 000000024905462X
Andrew J Mitchell1] The Centenary Institute, Newtown, New South Wales, Australia. [2].ORCID 000000034454853X
Ben RoedigerThe Centenary Institute, Newtown, New South Wales, Australia.
Anthony J BrzoskaSchool of Biological Sciences, University of Sydney, New South Wales, Australia.
Shweta TikooThe Centenary Institute, Newtown, New South Wales, Australia.
Qiang ChengCentre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia.
Lai Guan NgSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore.
Lois L Cavanagh1] The Centenary Institute, Newtown, New South Wales, Australia. [2] Sydney Medical School, New South Wales, Australia.
Ulrich H von AndrianImmune Disease Institute and Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
Michael J HickeyCentre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia.
Neville FirthSchool of Biological Sciences, University of Sydney, New South Wales, Australia.
Wolfgang Weninger1] The Centenary Institute, Newtown, New South Wales, Australia. [2] Discipline of Dermatology, Sydney Medical School, New South Wales, Australia. [3] Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.

Funding

T Cell Activation in Lymph NodesR01AI069259 · NIAID · IMMUNE DISEASE INSTITUTE, INC. · PI VON ANDRIAN, ULRICH H · 2006 to 2015
$4.5M
NIAID NIH HHS R01 AI069259
6 · The paper itself

Abstract

Transendothelial migration of neutrophils in postcapillary venules is a key event in the inflammatory response against pathogens and tissue damage. The precise regulation of this process is incompletely understood. We report that perivascular macrophages are critical for neutrophil migration into skin infected with the pathogen Staphylococcus aureus. Using multiphoton intravital microscopy we showed that neutrophils extravasate from inflamed dermal venules in close proximity to perivascular macrophages, which are a major source of neutrophil chemoattractants. The virulence factor α-hemolysin produced by S. aureus lyses perivascular macrophages, which leads to decreased neutrophil transmigration. Our data illustrate a previously unrecognized role for perivascular macrophages in neutrophil recruitment to inflamed skin and indicate that S. aureus uses hemolysin-dependent killing of these cells as an immune evasion strategy.

Indexed as

AnimalsBacterial ToxinsBlood VesselsFlow CytometryGene ExpressionHemolysin ProteinsLuminescent ProteinsMacrophagesMiceMice, Inbred C57BLMice, TransgenicMicroscopy, ConfocalMicroscopy, Fluorescence, MultiphotonNeutrophil InfiltrationNeutrophilsReverse Transcriptase Polymerase Chain ReactionBacterial ToxinsHemolysin ProteinsLuminescent Proteinsstaphylococcal alpha-toxin

Identifiers

PMID24270515
PMCPMC4097073

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.