Evidence map›Paper›PMID 24270405›Full record

ArticleCell death and differentiation2014

Prolyl isomerase Pin1 and protein kinase HIPK2 cooperate to promote cortical neurogenesis by suppressing Groucho/TLE:Hes1-mediated inhibition of neuronal differentiation.

R Ciarapica, L Methot, Y Tang, R Lo, R Dali, M Buscarlet, F Locatelli, G del Sal, R Rota, S Stifani

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death and differentiation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. HIPK2 in the physiology of nervous system and its implications in neurological disorders.Biochimica et biophysica acta. Molecular cell research · 2023
    Review
  6. Article
  7. Review
  8. Genes · 2021
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

R Ciarapica1] Montreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec H3A2B4, Canada [2] Department of Oncohematology, Ospedale Pediatrico Bambino Gesù, IRCCS, Roma, Italy.
L MethotMontreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec H3A2B4, Canada.
Y TangMontreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec H3A2B4, Canada.
R LoMontreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec H3A2B4, Canada.
R DaliMontreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec H3A2B4, Canada.
M BuscarletMontreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec H3A2B4, Canada.
F Locatelli1] Department of Oncohematology, Ospedale Pediatrico Bambino Gesù, IRCCS, Roma, Italy [2] University of Pavia, Pavia, Italy.
G del Sal1] Laboratorio Nazionale CIB, Area Science Park, Trieste, Italy [2] Dipartimento di Scienze della Vita, Università degli Studi di Trieste, Trieste, Italy.
R RotaDepartment of Oncohematology, Ospedale Pediatrico Bambino Gesù, IRCCS, Roma, Italy.
S StifaniMontreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec H3A2B4, Canada.
Istituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

Canadian Institutes of Health Research MOP-13957Canadian Institutes of Health Research MOP-42479
6 · The paper itself

Abstract

The Groucho/transducin-like Enhancer of split 1 (Gro/TLE1):Hes1 transcriptional repression complex acts in cerebral cortical neural progenitor cells to inhibit neuronal differentiation. The molecular mechanisms that regulate the anti-neurogenic function of the Gro/TLE1:Hes1 complex during cortical neurogenesis remain to be defined. Here we show that prolyl isomerase Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) and homeodomain-interacting protein kinase 2 (HIPK2) are expressed in cortical neural progenitor cells and form a complex that interacts with the Gro/TLE1:Hes1 complex. This association depends on the enzymatic activities of both HIPK2 and Pin1, as well as on the association of Gro/TLE1 with Hes1, but is independent of the previously described Hes1-activated phosphorylation of Gro/TLE1. Interaction with the Pin1:HIPK2 complex results in Gro/TLE1 hyperphosphorylation and weakens both the transcriptional repression activity and the anti-neurogenic function of the Gro/TLE1:Hes1 complex. These results provide evidence that HIPK2 and Pin1 work together to promote cortical neurogenesis, at least in part, by suppressing Gro/TLE1:Hes1-mediated inhibition of neuronal differentiation.

Indexed as

NeurogenesisAnimalsBasic Helix-Loop-Helix ProteinsCarrier ProteinsCell DifferentiationCell Line, TumorCells, CulturedCerebral CortexHEK293 CellsHomeodomain ProteinsHumansMiceNaphthoquinonesNeural Stem CellsNIMA-Interacting Peptidylprolyl IsomerasePeptidylprolyl IsomeraseBasic Helix-Loop-Helix ProteinsCarrier ProteinsHES1 protein, humanHIPK2 protein, humanHomeodomain ProteinsjugloneNaphthoquinonesNIMA-Interacting Peptidylprolyl IsomerasePeptidylprolyl IsomerasePIN1 protein, humanPin1 protein, mouseProtein Serine-Threonine KinasesRepressor ProteinsTranscription Factor HES-1Tretinoin

Identifiers

PMID24270405
PMCPMC3890956
OpenAlexW1968967577

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.