ArticleNature genetics2014
Minke whale genome and aquatic adaptation in cetaceans.
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Article in Nature genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers.
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150citing papers in PubMed
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150 citing papers in PubMed, 290 citations in OpenAlex.
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90 more citing papers are in PubMed but not listed here.
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Authors and funding
55 authors at 16 institutions in 7 countries.
Hyung-Soon Yim1] Korea Institute of Ocean Science and Technology, Ansan, Republic of Korea. [2].
Yun Sung Cho1] Personal Genomics Institute, Genome Research Foundation, Suwon, Republic of Korea. [2].
Xuanmin Guang1] Beijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China. [2].
Sung Gyun Kang1] Korea Institute of Ocean Science and Technology, Ansan, Republic of Korea. [2] Department of Marine Biotechnology, University of Science and Technology, Daejeon, Republic of Korea.
Jae-Yeon Jeong1] Korea Institute of Ocean Science and Technology, Ansan, Republic of Korea. [2] Department of Marine Biotechnology, University of Science and Technology, Daejeon, Republic of Korea.
Sun-Shin Cha1] Korea Institute of Ocean Science and Technology, Ansan, Republic of Korea. [2] Department of Marine Biotechnology, University of Science and Technology, Daejeon, Republic of Korea. [3] Ocean Science and Technology School, Korea Maritime University, Busan, Republic of Korea.
Hyun-Myung OhKorea Institute of Ocean Science and Technology, Ansan, Republic of Korea.
Jae-Hak LeeKorea Institute of Ocean Science and Technology, Ansan, Republic of Korea.
Eun Chan YangKorea Institute of Ocean Science and Technology, Ansan, Republic of Korea.
Kae Kyoung Kwon1] Korea Institute of Ocean Science and Technology, Ansan, Republic of Korea. [2] Department of Marine Biotechnology, University of Science and Technology, Daejeon, Republic of Korea.
Yun Jae KimKorea Institute of Ocean Science and Technology, Ansan, Republic of Korea.
Tae Wan KimKorea Institute of Ocean Science and Technology, Ansan, Republic of Korea.
Wonduck KimKorea Institute of Ocean Science and Technology, Ansan, Republic of Korea.
Jeong Ho JeonKorea Institute of Ocean Science and Technology, Ansan, Republic of Korea.
Sang-Jin Kim1] Korea Institute of Ocean Science and Technology, Ansan, Republic of Korea. [2] Department of Marine Biotechnology, University of Science and Technology, Daejeon, Republic of Korea.
Dong Han ChoiKorea Institute of Ocean Science and Technology, Ansan, Republic of Korea.
Sungwoong JhoPersonal Genomics Institute, Genome Research Foundation, Suwon, Republic of Korea.
Hak-Min KimPersonal Genomics Institute, Genome Research Foundation, Suwon, Republic of Korea.
Junsu KoTheragen BiO Institute, TheragenEtex, Suwon, Republic of Korea.
Hyunmin KimTheragen BiO Institute, TheragenEtex, Suwon, Republic of Korea.
Young-Ah ShinPersonal Genomics Institute, Genome Research Foundation, Suwon, Republic of Korea.
Hyun-Ju JungTheragen BiO Institute, TheragenEtex, Suwon, Republic of Korea.
Yuan ZhengBeijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China.
Zhuo WangBeijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China.
Yan ChenBeijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China.
Ming ChenBeijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China.
Awei JiangBeijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China.
Erli LiBeijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China.
Shu ZhangBeijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China.
Haolong HouShaanxi Yulin Energy Group Co. Ltd., Yulin, Shaanxi, China.
Tae Hyung KimTheragen BiO Institute, TheragenEtex, Suwon, Republic of Korea.
Lili YuBeijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China.
Sha LiuBeijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China.
Kung AhnTheragen BiO Institute, TheragenEtex, Suwon, Republic of Korea.
Jesse CooperTheragen BiO Institute, TheragenEtex, Suwon, Republic of Korea.
Sin-Gi ParkTheragen BiO Institute, TheragenEtex, Suwon, Republic of Korea.
Chang Pyo HongTheragen BiO Institute, TheragenEtex, Suwon, Republic of Korea.
Wook JinDepartment of Molecular Medicine, School of Medicine, Gachon University, Incheon, Republic of Korea.
Heui-Soo KimDepartment of Biological Sciences, College of Natural Sciences, Pusan National University, Busan, Republic of Korea.
Chankyu ParkLaboratory of Genome Biology, Department of Animal Biotechnology, Konkuk University, Seoul, Republic of Korea.
Kyooyeol LeeLaboratory of Genome Biology, Department of Animal Biotechnology, Konkuk University, Seoul, Republic of Korea.
Sung ChunDivision of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Phillip A MorinMarine Mammal and Turtle Division, Southwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, La Jolla, California, USA.
Stephen J O'BrienTheodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University, St. Petersburg, Russia.
Hang LeeCollege of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
Jumpei KimuraDepartment of Anatomy and Cell Biology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
Dae Yeon MoonMarine Biodiversity Institute of Korea (MABIK), Ministry of Ocean and Fisheries, Sejong, Republic of Korea.
Andrea ManicaEvolutionary Ecology Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Jeremy EdwardsDepartment of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Byung Chul KimPersonal Genomics Institute, Genome Research Foundation, Suwon, Republic of Korea.
Sangsoo KimSchool of Systems Biomedical Science, Soongsil University, Seoul, Republic of Korea.
Jun Wang1] Beijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China. [2] Department of Biology, University of Copenhagen, Copenhagen, Denmark. [3] King Abdulaziz University, Jeddah, Saudi Arabia.
Jong Bhak1] Personal Genomics Institute, Genome Research Foundation, Suwon, Republic of Korea. [2] Theragen BiO Institute, TheragenEtex, Suwon, Republic of Korea. [3] Program in Nano Science and Technology, Department of Transdisciplinary Studies, Seoul National University, Suwon, Republic of Korea. [4] Advanced Institutes of Convergence Technology Nano Science and Technology, Suwon, Republic of Korea.ORCID 0000000242281299
Hyun Sook Lee1] Korea Institute of Ocean Science and Technology, Ansan, Republic of Korea. [2] Department of Marine Biotechnology, University of Science and Technology, Daejeon, Republic of Korea.
Jung-Hyun Lee1] Korea Institute of Ocean Science and Technology, Ansan, Republic of Korea. [2] Department of Marine Biotechnology, University of Science and Technology, Daejeon, Republic of Korea.
Korea Institute of Ocean Science and Technology · KRBGI Group (China) · CNGenome Research Foundation · KRTheragen · KRKonkuk University · KRBrigham and Women's Hospital · USGachon University · KRMarine Biodiversity Institute of Korea · KRNOAA National Marine Fisheries Service · USSeoul National University · KRSeoul National University of Science and Technology · KRShaanxi Yulin Energy Group · CNSt Petersburg University · RUUniversity of Cambridge · GBUniversity of Copenhagen · DKUniversity of New Mexico · US
Funding
Polony Sequencing and the $1000 Genome R01HG005852 · NHGRI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI EDWARDS, JEREMY S · 2010 to 2012
$2.7MHaplotype Resolved Sequencing TechnologyR01HG006876 · NHGRI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI EDWARDS, JEREMY S · 2013 to 2015
$1.3MA Spatially coarse-grained, rule-based frame work for modeling large molecularR01GM104973 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI EDWARDS, JEREMY S · 2012 to 2015
$1.3MNHGRI NIH HHS R01 HG005852NHGRI NIH HHS R01 HG006876NIGMS NIH HHS R01 GM104973
Abstract
The shift from terrestrial to aquatic life by whales was a substantial evolutionary event. Here we report the whole-genome sequencing and de novo assembly of the minke whale genome, as well as the whole-genome sequences of three minke whales, a fin whale, a bottlenose dolphin and a finless porpoise. Our comparative genomic analysis identified an expansion in the whale lineage of gene families associated with stress-responsive proteins and anaerobic metabolism, whereas gene families related to body hair and sensory receptors were contracted. Our analysis also identified whale-specific mutations in genes encoding antioxidants and enzymes controlling blood pressure and salt concentration. Overall the whale-genome sequences exhibited distinct features that are associated with the physiological and morphological changes needed for life in an aquatic environment, marked by resistance to physiological stresses caused by a lack of oxygen, increased amounts of reactive oxygen species and high salt levels.
Indexed as
GenomeAdaptation, PhysiologicalAnimalsBlood PressureGlutathioneHaptoglobinsMaleMinke WhaleMultigene FamilyMutationPacific OceanPhylogenyPopulation DensitySalt ToleranceStress, PhysiologicalGlutathioneHaptoglobins
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