Evidence map›Paper›PMID 24269844›Full record

ReviewBiochimica et biophysica acta2014

Sec-secretion and sortase-mediated anchoring of proteins in Gram-positive bacteria.

Olaf Schneewind, Dominique Missiakas

Open access · greenAbstract readReview
In one paragraph

Review in Biochimica et biophysica acta, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 147 citations in OpenAlex.

  1. Mislocalization of PBPs inMicrobiology spectrum · 2026
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  3. Global Transcriptional Differences inAntibiotics (Basel, Switzerland) · 2026
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  12. In vivo virulence ofJTCVS open · 2025
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  20. Maple compounds prevent biofilm formation inFrontiers in microbiology · 2024
    Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Olaf SchneewindDepartment of Microbiology, University of Chicago, Chicago, IL 60637, USA. Electronic address: oschnee@bsd.uchicago.edu.
Dominique MissiakasDepartment of Microbiology, University of Chicago, Chicago, IL 60637, USA.
University of Chicago · US

Funding

Vaccines and Therapies Against BotulismU54AI057153 · NIAID · UNIVERSITY OF CHICAGO · PI SCHNEEWIND, OLAF · 2003 to 2013
$87.6M
Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
Surface Proteins of Gram-Positive BacteriaR01AI038897 · NIAID · UNIVERSITY OF CHICAGO · PI MISSIAKAS, DOMINIQUE M. · 1996 to 2024
$8.9M
Vaccine Assembly from Surface Proteins of Staphylococcus AureusR01AI052474 · NIAID · UNIVERSITY OF CHICAGO · PI Dominique Missiakas · 2002 to 2026
$8.8M
ESAT-6 Secretion in Staphylococcus AureusR01AI075258 · NIAID · UNIVERSITY OF CHICAGO · PI MISSIAKAS, DOMINIQUE M. · 2009 to 2013
$1.9M
Prototype Fabrication of a Cell Migration SensorR41AI052747 · NIAID · RAINMAKER TECHNOLOGY, INC. · PI SALDIVAR, ENRIQUE · 2002 to 2002
$122k
NCATS NIH HHS UL1 TR000430NIAID NIH HHS 1-U54-AI-057153NIAID NIH HHS AI038897NIAID NIH HHS AI052747NIAID NIH HHS AI075258NIAID NIH HHS R01 AI038897NIAID NIH HHS R01 AI052474NIAID NIH HHS R01 AI075258NIAID NIH HHS U54 AI057153
6 · The paper itself

Abstract

Signal peptide-driven secretion of precursor proteins directs polypeptides across the plasma membrane of bacteria. Two pathways, Sec- and SRP-dependent, converge at the SecYEG translocon to thread unfolded precursor proteins across the membrane, whereas folded preproteins are routed via the Tat secretion pathway. Gram-positive bacteria lack an outer membrane and are surrounded by a rigid layer of peptidoglycan. Interactions with their environment are mediated by proteins that are retained in the cell wall, often through covalent attachment to the peptidoglycan. In this review, we describe the mechanisms for both Sec-dependent secretion and sortase-dependent assembly of proteins in the envelope of Gram-positive bacteria. This article is part of a Special Issue entitled: Protein trafficking and secretion in bacteria. Guest Editors: Anastassios Economou and Ross Dalbey.

Indexed as

AminoacyltransferasesBacterial ProteinsCell MembraneCell WallCysteine EndopeptidasesGram-Positive BacteriaPeptidoglycanProtein Sorting SignalsProtein TransportAminoacyltransferasesBacterial ProteinsCysteine EndopeptidasesPeptidoglycanProtein Sorting Signalssortase ACell wallLeader peptideLPXTGPeptidoglycanSecSortase

Identifiers

PMID24269844
PMCPMC4031296
OpenAlexW2015154615

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.