ArticleNeuroImage2014
Individual differences in the morphometry and activation of time perception networks are influenced by dopamine genotype.
Article in NeuroImage, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Dopamine, time perception, and future time perspective.Psychopharmacology · 2018Trial
- Approaching background sounds extend the duration of foreground auditory stimuli.Scientific reports · 2026Article
- Sex based differences in time processing were found in newly developed tasks.Psychological research · 2026Article
- VNTR Polymorphisms in theBioengineering (Basel, Switzerland) · 2025Article
- Time to inhibit: P300 amplitude differences in individuals with high and low temporal efficiency.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Article
- Article
- Characteristics of psychological time in patients with depression and potential intervention strategies.Frontiers in psychiatry · 2023Review
- A proxy measure of striatal dopamine predicts individual differences in temporal precision.Psychonomic bulletin & review · 2022Article
- How movements shape the perception of time.Trends in cognitive sciences · 2021Review
- Similar CNV Neurodynamic Patterns between Sub- and Supra-Second Time Perception.Brain sciences · 2021Article
- An fMRI Study Using a Combined Task of Interval Discrimination and Oddball Could Reveal Common Brain Circuits of Cognitive Change.Frontiers in psychiatry · 2021Article
- Motor Synchronization to Rhythmic Auditory Stimulation (RAS) Attenuates Dopaminergic Responses in Ventral Striatum in Young Healthy Adults: [Frontiers in neuroscience · 2019Article
- Changes in Magnitude and Variability of Corticospinal Excitability During Rewarded Time-Sensitive Behavior.Frontiers in behavioral neuroscience · 2019Article
- Genetic influence alters the brain synchronism in perception and timing.Journal of biomedical science · 2018Review
- Neurochemical changes in basal ganglia affect time perception in parkinsonians.Journal of biomedical science · 2018Review
- Reduced structural complexity of the right cerebellar cortex in male children with autism spectrum disorder.PloS one · 2018Article
- Article
- Imaging genetics in neurodevelopmental psychopathology.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- DRD2: Bridging the Genome and Ingestive Behavior.Trends in cognitive sciences · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Individual participants vary greatly in their ability to estimate and discriminate intervals of time. This heterogeneity of performance may be caused by reliance on different time perception networks as well as individual differences in the activation of brain structures utilized for timing within those networks. To address these possibilities we utilized event-related functional magnetic resonance imaging (fMRI) while human participants (n=25) performed a temporal or color discrimination task. Additionally, based on our previous research, we genotyped participants for DRD2/ANKK1-Taq1a, a single-nucleotide polymorphism associated with a 30-40% reduction in striatal D2 density and associated with poorer timing performance. Similar to previous reports, a wide range of performance was found across our sample; crucially, better performance on the timing versus color task was associated with greater activation in prefrontal and sub-cortical regions previously associated with timing. Furthermore, better timing performance also correlated with increased volume of the right lateral cerebellum, as demonstrated by voxel-based morphometry. Our analysis also revealed that A1 carriers of the Taq1a polymorphism exhibited relatively worse performance on temporal, but not color discrimination, but greater activation in the striatum and right dorsolateral prefrontal cortex, as well as reduced volume in the cerebellar cluster. These results point to the neural bases for heterogeneous timing performance in humans, and suggest that differences in performance on a temporal discrimination task are, in part, attributable to the DRD2/ANKK1 genotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.