Evidence map›Paper›PMID 24269592›Full record

ReviewThe American journal of pathology2014

Exosomes: a novel pathway of local and distant intercellular communication that facilitates the growth and metastasis of neoplastic lesions.

Huang-Ge Zhang, William E Grizzle

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The American journal of pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 224 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
224citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

224 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  8. Extracellular vesicles in spine tumors: biological roles, immune modulation, and therapeutic implications.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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164 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Huang-Ge ZhangDepartment of Microbiology and Immunology, University of Louisville, Louisville, Kentucky.
William E GrizzleDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address: wgrizzle@uab.edu.

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Treatment of HIV- and HIV+ Patients with HPV16+ CIN2/3 Using pNGLV4a-hCRTE6E7L2 DNA vaccine administered intramuscularly via electroporationP50CA098252 · NCI · JOHNS HOPKINS UNIVERSITY · PI Richard Bruce Roden · 2003 to 2026
$53.5M
TRAINING AND CAREER DEVELOPMENTU54CA118948 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Timiya S Nolan · 2005 to 2026
$26.6M
UAB Rexinoids for Breast Cancer PreventionP50CA089019 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GRIZZLE, WILLIAM E. · 2000 to 2011
$26.0M
UAB / UMN SPORE in Pancreatic CancerP50CA101955 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BUCHSBAUM, DONALD J · 2010 to 2014
$11.1M
UAB Skin Diseases Research CenterP30AR050948 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ELMETS, CRAIG A · 2004 to 2013
$5.5M
Phosphodiesterase 5: A Novel Target and Inhibitor for Breast Cancer ChemopreventionR01CA155638 · NCI · UNIVERSITY OF SOUTH ALABAMA · PI PIAZZA, GARY A · 2012 to 2017
$2.3M
Curcumin reverses tumor exosomes-mediated inhibition of myeloid differentiationR01AT004294 · NCCIH · UNIVERSITY OF LOUISVILLE · PI ZHANG, HUANG-GE · 2007 to 2010
$1.4M
Breast tumor exosomal Jak3BP mediated immunosuppressionR01CA116092 · NCI · UNIVERSITY OF LOUISVILLE · PI ZHANG, HUANG-GE · 2005 to 2011
$1.3M
Age related ubiquitin defect on T-cell response to tumorR01CA107181 · NCI · UNIVERSITY OF LOUISVILLE · PI ZHANG, HUANG-GE · 2005 to 2009
$1.1M
lung tumor exosome-mediated inflammation promotes tumor progression and growthR01CA137037 · NCI · UNIVERSITY OF LOUISVILLE · PI ZHANG, HUANG-GE · 2009 to 2010
$616k
NCCIH NIH HHS R01 AT004294NCCIH NIH HHS R01AT004294NCI NIH HHS 1R01CA155638-01A1NCI NIH HHS 2P50CA101955NCI NIH HHS 2U54CA118948NCI NIH HHS 5P50CA089019NCI NIH HHS 5P50CA098252NCI NIH HHS P30 CA013148NCI NIH HHS P50 CA089019NCI NIH HHS P50 CA098252NCI NIH HHS P50 CA101955NCI NIH HHS R01 CA107181NCI NIH HHS R01CA107181NCI NIH HHS R01 CA116092NCI NIH HHS R01CA116092NCI NIH HHS R01 CA137037NCI NIH HHS R01CA137037NCI NIH HHS R01 CA155638NCI NIH HHS U54 CA118948NIAMS NIH HHS P30 AR050948NIAMS NIH HHS P30AR50948-04
6 · The paper itself

Abstract

Normal and diseased cells release bilayered membrane-bound nanovesicles into interstitial spaces and into bodily fluids. A subgroup of such microvesicles is called exosomes and is described in blood as 30 to 100 nm in diameter and as spherical to cup-shaped nanoparticles with specific surface molecular characteristics (eg, expression of the tetraspanins CD9, CD81, and CD63). Extracellular microvesicles provide local signals (eg, autocrine and paracrine) and distant endocrine signals to cells via the transfer of their contents, which include signal proteins, lipids, miRNAs, and functional mRNAs. Exosomes and related microvesicles also aid cells in exporting less-needed molecules and potentially harmful molecules, including drugs; in the case of neoplasia, the export of chemotherapeutic drugs may facilitate cellular chemoresistance. Cancers have adapted the exosome and related microvesicles as a pathway by which neoplastic cells communicate with each other (autocrine) and with nonneoplastic cells (paracrine and endocrine); via this pathway, cancer suppresses the immune system and establishes a fertile local and distant environment to support neoplastic growth, invasion, and metastases. Because exosomes mirror and bind to the cells from which they arise, they can be used for delivery of drugs, vaccines, and gene therapy, as biomarkers and targets. We review how exosomes and related extracellular microvesicles facilitate the progression and metastases of cancers and describe how these microvesicles may affect clinical care.

Indexed as

AnimalsExomeHumansNeoplasms

Identifiers

PMID24269592
PMCPMC3873490

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.