Evidence map›Paper›PMID 24269175›Full record

ArticleJournal of neuroscience methods2014

A pelvic implant orthosis in rodents, for spinal cord injury rehabilitation, and for brain machine interface research: construction, surgical implantation and validation.

Ubong Ime Udoekwere, Chintan S Oza, Simon F Giszter

Open access · greenAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience methods, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Motor primitives are determined in early development and are then robustly conserved into adulthood.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  2. Teaching Adult Rats Spinalized as Neonates to Walk Using Trunk Robotic Rehabilitation: Elements of Success, Failure, and Dependence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ubong Ime UdoekwereDrexel University College of Medicine, and School of Biomedical Engineering and Health Science, Drexel University, Philadelphia, PA, USA; OREC - Orthopaedic and Rehabilitation Engineering Center, Marquette University, Milwaukee, WI, USA.
Chintan S OzaDrexel University College of Medicine, and School of Biomedical Engineering and Health Science, Drexel University, Philadelphia, PA, USA.
Simon F GiszterDrexel University College of Medicine, and School of Biomedical Engineering and Health Science, Drexel University, Philadelphia, PA, USA. Electronic address: sgiszter@drexelmed.edu.
Drexel University · US

Funding

Multielectrode recording in spinal cord during locomotion and rehabilitation afteR01NS072651 · NINDS · DREXEL UNIVERSITY · PI GISZTER, SIMON F · 2010 to 2014
$1.6M
Neurorobotics, modularity and function in SCI and Normal RatsR01NS054894 · NINDS · DREXEL UNIVERSITY · PI GISZTER, SIMON F · 2008 to 2012
$1.5M
NINDS NIH HHS NS054894NINDS NIH HHS R01 NS054894NINDS NIH HHS R01 NS072651Wellcome Trust 072651
6 · The paper itself

Abstract

backgroundRodents are important model systems used to explore spinal cord injury (SCI) and rehabilitation, and brain machine interfaces (BMI). We present a new method to provide mechanical interaction for BMI and rehabilitation in rat models of SCI. NEW

methodWe present the design and implantation procedures for a pelvic orthosis that allows direct force application to the skeleton in brain machine interface and robot rehabilitation applications in rodents. We detail the materials, construction, machining, surgery and validation of the device.

resultsWe describe the statistical validation of the implant procedures by comparing stepping parameters of 8 rats prior to and after implantation and surgical recovery. An ANOVA showed no effects of the implantation on stepping. Paired tests in the individual rats also showed no effect in 7/8 rats and minor effects in the last rat, within the group's variance. COMPARISON WITH EXISTING

methodsOur method allows interaction with rats at the pelvis without any perturbation of normal stepping in the intact rat. The method bypasses slings, and cuffs, avoiding cuff or slings squeezing the abdomen, or other altered sensory feedback. Our implant osseointegrates, and thus allows an efficient high bandwidth mechanical coupling to a robot. The implants support quadrupedal training and are readily integrated into either treadmill or overground contexts.

conclusionsOur novel device and procedures support a range of novel experimental designs and motor tests for rehabilitative and augmentation devices in intact and SCI model rats, with the advantage of allowing direct force application at the pelvic bones.

Indexed as

Brain-Computer InterfacesImplants, ExperimentalOrthotic DevicesPelvisAnalysis of VarianceAnimalsBiomechanical PhenomenaFemaleHindlimbHip JointJointsLocomotionOrthopedic ProceduresRatsRats, Sprague-DawleyRoboticsBiomechanic perturbationsBrain machine interfaceLocomotionNeuroroboticsRobot rehabilitation

Identifiers

PMID24269175
PMCPMC4065419
OpenAlexW2037151803

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.