Evidence map›Paper›PMID 24268663›Full record

ArticleBiomaterials2014

Three-dimensional filamentous human diseased cardiac tissue model.

Zhen Ma, Sangmo Koo, Micaela A Finnegan, Peter Loskill, Nathaniel Huebsch, Natalie C Marks, Bruce R Conklin, Costas P Grigoropoulos, Kevin E Healy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 111 citations in OpenAlex.

  1. Review
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  12. Cardiac Disease Modeling with Engineered Heart Tissue.Handbook of experimental pharmacology · 2023
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  20. Reconstructing the heart using iPSCs: Engineering strategies and applications.Journal of molecular and cellular cardiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Zhen MaDepartment of Bioengineering, University of California, Berkeley, CA 94720, USA.
Sangmo KooDepartment of Mechanical Engineering, University of California, Berkeley, CA 94720, USA.
Micaela A FinneganDepartment of Bioengineering, University of California, Berkeley, CA 94720, USA.
Peter LoskillDepartment of Bioengineering, University of California, Berkeley, CA 94720, USA.
Nathaniel HuebschGladstone Institute of Cardiovascular Disease, San Francisco, CA 94143, USA; Department of Medicine, University of California, San Francisco, CA 94143, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA.
Natalie C MarksDepartment of Bioengineering, University of California, Berkeley, CA 94720, USA.
Bruce R ConklinGladstone Institute of Cardiovascular Disease, San Francisco, CA 94143, USA; Department of Medicine, University of California, San Francisco, CA 94143, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA.
Costas P GrigoropoulosDepartment of Mechanical Engineering, University of California, Berkeley, CA 94720, USA.
Kevin E HealyDepartment of Bioengineering, University of California, Berkeley, CA 94720, USA; Department of Material Science and Engineering, University of California, Berkeley, CA 94720, USA. Electronic address: kehealy@berkeley.edu.
University of California, Berkeley · USUniversity of California, San Francisco · US

Funding

The Epigenetic Landscape of Heart DevelopmentU01HL098179 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BOYER, LAURIE A, BRUNEAU, BENOIT GAETAN · 2009 to 2014
$10.0M
Induced Pluripotent Stem Cells in the Understanding and Treatment of Heart DiseasU01HL100406 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BRUNEAU, BENOIT GAETAN, CONKLIN, BRUCE R · 2009 to 2015
$9.4M
Modeling metabolic interactions of liver and fat with integrated microphysiological systemsUH3TR000487 · NCATS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HEALY, KEVIN EDWARD · 2014 to 2016
$2.9M
Disease Specific Cardiac Tissue ModelsR01HL108677 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI CONKLIN, BRUCE R, HEALY, KEVIN EDWARD · 2011 to 2014
$2.4M
Disease-Specific Integrated Microphysiological Human Tissue ModelsUH2TR000487 · NCATS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HEALY, KEVIN EDWARD, LEE, LUKE P. · 2012 to 2013
$1.8M
Enabling Technologies for hES Cell Self-RenewalR01HL096525 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI HEALY, KEVIN EDWARD · 2009 to 2013
$1.8M
NCATS NIH HHS UH2 TR000487NCATS NIH HHS UH2TR000487NCATS NIH HHS UH3 TR000487NHLBI NIH HHS R01 HL096525NHLBI NIH HHS R01HL096525NHLBI NIH HHS R01 HL108677NHLBI NIH HHS R01HL108677NHLBI NIH HHS U01 HL098179NHLBI NIH HHS U01HL098179NHLBI NIH HHS U01 HL100406NHLBI NIH HHS U01HL100406
6 · The paper itself

Abstract

A human in vitro cardiac tissue model would be a significant advancement for understanding, studying, and developing new strategies for treating cardiac arrhythmias and related cardiovascular diseases. We developed an in vitro model of three-dimensional (3D) human cardiac tissue by populating synthetic filamentous matrices with cardiomyocytes derived from healthy wild-type volunteer (WT) and patient-specific long QT syndrome type 3 (LQT3) induced pluripotent stem cells (iPS-CMs) to mimic the condensed and aligned human ventricular myocardium. Using such a highly controllable cardiac model, we studied the contractility malfunctions associated with the electrophysiological consequences of LQT3 and their response to a panel of drugs. By varying the stiffness of filamentous matrices, LQT3 iPS-CMs exhibited different level of contractility abnormality and susceptibility to drug-induced cardiotoxicity.

Indexed as

Models, BiologicalCase-Control StudiesCell DifferentiationDrug Evaluation, PreclinicalFlow CytometryHumansInduced Pluripotent Stem CellsLong QT SyndromeMicroscopy, Atomic ForceMicroscopy, Electron, ScanningReal-Time Polymerase Chain ReactionCardiac contractilityCardiac disease modelDrug testingInduced pluripotent stem cellsLong QT syndromeTwo-photon initiated polymerization

Identifiers

PMID24268663
PMCPMC3900500
OpenAlexW2015522879

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.