ArticleBiomaterials2014
Regulation of migratory activity of human keratinocytes by topography of multiscale collagen-containing nanofibrous matrices.
Article in Biomaterials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 62 citations in OpenAlex.
- Form Meets Function: Fiber Architecture Directs Proliferation and Differentiation in Gingival Keratinocytes.Cells · 2026Article
- A multidimensional platform to support intestinal epithelial and immune cell co-culture.Frontiers in nutrition · 2026Article
- Three-Dimensional Culture of Epithelial Cells on Electrospun Nanofibrous Scaffolds.International journal of molecular sciences · 2025Review
- Microvesicle-eluting nano-engineered implants influence inflammatory response of keratinocytes.Drug delivery and translational research · 2024Article
- Dermal stiffness governs the topography of the epidermis and the underlying basement membrane in young and old human skin.Aging cell · 2024Article
- Utilizing Fish Skin of Ikan Belida (Marine drugs · 2022Article
- Bioactive Materials Promote Wound Healing through Modulation of Cell Behaviors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Polyphosphazenes enable durable, hemocompatible, highly efficient antibacterial coatings.Biomaterials · 2021Article
- The Human Epidermal Basement Membrane: A Shaped and Cell Instructive Platform That Aging Slowly Alters.Biomolecules · 2020Review
- Si substituted hydroxyapatite nanorods on Ti for percutaneous implants.Bioactive materials · 2020Article
- Electrospun gelatin-polyethylenimine blend nanofibrous scaffold for biomedical applications.Journal of materials science. Materials in medicine · 2019Article
- Fabrication and preliminary in vitro evaluation of ultraviolet-crosslinked electrospun fish scale gelatin nanofibrous scaffolds.Journal of materials science. Materials in medicine · 2019Article
- A two-layer skin construct consisting of a collagen hydrogel reinforced by a fibrin-coated polylactide nanofibrous membrane.International journal of nanomedicine · 2019Article
- Subcellular topography modulates actin dynamics and signaling in B-cells.Molecular biology of the cell · 2018Article
- Biomaterials for Skin Substitutes.Advanced healthcare materials · 2018Review
- Cell-based cytotoxicity assays for engineered nanomaterials safety screening: exposure of adipose derived stromal cells to titanium dioxide nanoparticles.Journal of nanobiotechnology · 2017Article
- Biochemical and Biophysical Cues in Matrix Design for Chronic and Diabetic Wound Treatment.Tissue engineering. Part B, Reviews · 2017Article
- Protein nanocoatings on synthetic polymeric nanofibrous membranes designed as carriers for skin cells.International journal of nanomedicine · 2017Article
- Three-dimensional culture and interaction of cancer cells and dendritic cells in an electrospun nano-submicron hybrid fibrous scaffold.International journal of nanomedicine · 2016Article
- Rapid creation of skin substitutes from human skin cells and biomimetic nanofibers for acute full-thickness wound repair.Burns : journal of the International Society for Burn Injuries · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Nanofibrous matrices hold great promise in skin wound repair partially due to their capability of recapturing the essential attributes of native extracellular matrix (ECM). With regard to limited studies on the effect of nanofibrous matrices on keratinocytes, the present study was aimed to understand how the topographical feature of nanofibrous matrices regulates keratinocyte motility by culturing keratinocytes on polycaprolactone (PCL)/collagen nanofibrous matrices (rough surface with fiber diameters of 331 ± 112 nm) or the matrices coated with a thin layer of collagen gel to form a secondary ultrafine fibrous network (smooth surface with ultrafine fiber diameters of 55 ± 26 nm). It was found that the PCL/collagen nanofibrous matrices alone did not stimulate cell migration, while collagen gel coating could significantly increase cell motility. Further studies demonstrated that the ultrafine fibrous network of collagen gel coating significantly activated integrin β1, Rac1 and Cdc42, facilitated the deposition of laminin-332 (formerly called laminin-5), and promoted the expression of active matrix metalloproteinases (MMPs) (i.e., MMP-2 and 9). Neutralization of integrin β1 activity abrogated the gel coating-induced keratinocyte migration. These findings provide important evidence on the role of topographical features of nanofibrous matrices in regulating the phenotypic alteration of keratinocytes and suggest the possible utility of collagen-containing nanofibrous matrices for skin regeneration especially in re-epithelialization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.