ArticleBiophysical journal2013
Interplay between velocity and travel distance of kinesin-based transport in the presence of tau.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Advances in Alzheimer's disease: mechanistic insights and therapeutic targets.Science China. Life sciences · 2026Review
- Multiple kinesins speed up cargo transport in crowded environments by sharing load.Communications biology · 2025Article
- Interaction of Tau with Kinesin-1: Effect of Kinesin-1 Heavy Chain Elimination on Autophagy-Mediated Mutant Tau Degradation.Biomedicines · 2023Article
- Tau; One Protein, So Many Diseases.Biology · 2023Review
- Cholesterol in the cargo membrane amplifies tau inhibition of kinesin-1-based transport.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Membrane mediated motor kinetics in microtubule gliding assays.Scientific reports · 2019Article
- Native kinesin-1 does not bind preferentially to GTP-tubulin-rich microtubules in vitro.Cytoskeleton (Hoboken, N.J.) · 2017Article
- The axonal transport motor kinesin-2 navigates microtubule obstacles via protofilament switching.Traffic (Copenhagen, Denmark) · 2017Article
- Physiological and pathophysiological functions of Swiprosin-1/EFhd2 in the nervous system.The Biochemical journal · 2016Review
- Quantitative Determination of the Probability of Multiple-Motor Transport in Bead-Based Assays.Biophysical journal · 2016Article
- Microtubule Defects Influence Kinesin-Based Transport In Vitro.Biophysical journal · 2016Article
- Importance of anisotropy in detachment rates for force production and cargo transport by a team of motor proteins.Protein science : a publication of the Protein Society · 2016Article
- Cytoskeletal Network Morphology Regulates Intracellular Transport Dynamics.Biophysical journal · 2015Article
- Connecting the dots between tau dysfunction and neurodegeneration.Trends in cell biology · 2015Review
- Cooperative protofilament switching emerges from inter-motor interference in multiple-motor transport.Scientific reports · 2014Article
- Kinesin's neck-linker determines its ability to navigate obstacles on the microtubule surface.Biophysical journal · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Although the disease-relevant microtubule-associated protein tau is known to severely inhibit kinesin-based transport in vitro, the potential mechanisms for reversing this detrimental effect to maintain healthy transport in cells remain unknown. Here we report the unambiguous upregulation of multiple-kinesin travel distance despite the presence of tau, via decreased single-kinesin velocity. Interestingly, the presence of tau also modestly reduced cargo velocity in multiple-kinesin transport, and our stochastic simulations indicate that the tau-mediated reduction in single-kinesin travel underlies this observation. Taken together, our observations highlight a nontrivial interplay between velocity and travel distance for kinesin transport, and suggest that single-kinesin velocity is a promising experimental handle for tuning the effect of tau on multiple-kinesin travel distance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.