ArticleBiophysical journal2013
Physical explanation of coupled cell-cell rotational behavior and interfacial morphology: a particle dynamics model.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Quantitative videomicroscopy reveals latent control of cell-pair rotations in vivo.Development (Cambridge, England) · 2023Article
- Multi-Compartment Lymph-Node-on-a-Chip Enables Measurement of Immune Cell Motility in Response to Drugs.Bioengineering (Basel, Switzerland) · 2021Article
- Physical models of collective cell motility: from cell to tissue.Journal of physics D: Applied physics · 2017Article
- Modeling cell shape and dynamics on micropatterns.Cell adhesion & migration · 2016Article
- Cells as strain-cued automata.Journal of the mechanics and physics of solids · 2016Article
- Coherent Motion of Monolayer Sheets under Confinement and Its Pathological Implications.PLoS computational biology · 2015Article
- Polarity mechanisms such as contact inhibition of locomotion regulate persistent rotational motion of mammalian cells on micropatterns.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Coherent motions in confluent cell monolayer sheets.Biophysical journal · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have reported persistent rotational behavior between adherent cell-cell pairs cultured on micropatterned substrates, and this rotation is often accompanied by a sigmoidal deflection of the cell-cell interface. Interestingly, the cell-cell rotation runs in the opposite reference frame from what could be expected of single cell locomotion. Specifically, the rotation of the cell pair consists of each individual cell protruding from the inwardly regressive arm of the cell-cell interface, and retracting from the other outwardly protrusive arm. To this author's knowledge, the cause of this elusive behavior has not yet been clarified. Here, we propose a physical model based on particle dynamics, accounting for actomyosin forcing, viscous dissipation, and cortical tension. The results show that a correlation in actomyosin force vectors leads to both persistent rotational behavior and interfacial deflection in a simulated cell cluster. Significantly, the model, without any artificial cues, spontaneously and consistently reproduces the same rotational reference frame as experimentally observed. Further analyses show that the interfacial deflection depends predominantly on cortical tension, whereas the cluster rotation depends predominantly on actomyosin forcing. Together, these results corroborate the hypothesis that both rotational and morphological phenomena are, in fact, physically coupled by an intracellular torque of a common origin.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.