ArticleBMC surgery2013
Impact of parathyroidectomy on cardiovascular outcomes and survival in chronic hemodialysis patients with secondary hyperparathyroidism. A retrospective study of 50 cases prior to the calcimimetics era.
Article in BMC surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Pooled it
- Management of pre-renal transplant secondary hyperparathyroidism: parathyroidectomy versus cinacalcet.Drugs in context · 2023Article
- Impact of parathyroidectomy among nondiabetic hemodialysis patients with severe hyperparathyroidism.Renal failure · 2022Article
- Lanthionine, a Novel Uremic Toxin, in the Vascular Calcification of Chronic Kidney Disease: The Role of Proinflammatory Cytokines.International journal of molecular sciences · 2021Article
- Secondary Hyperparathyroidism and Hypertension: An Intriguing Couple.Journal of clinical medicine · 2020Review
- Effects of Social Disparities on Management and Surgical Outcomes for Patients with Secondary Hyperparathyroidism.World journal of surgery · 2020Article
- Cardiovascular and Cerebrovascular Events After Parathyroidectomy in Patients on Renal Replacement Therapy.World journal of surgery · 2019Article
- Calcimimetics versus parathyroidectomy: What is preferable?International urology and nephrology · 2018Review
- Zebrafish, a Novel Model System to Study Uremic Toxins: The Case for the Sulfur Amino Acid Lanthionine.International journal of molecular sciences · 2018Article
- Risk of acute coronary syndrome after parathyroidectomy in patients with end-stage renal disease: A population-based cohort study in Taiwan.Nephrology (Carlton, Vic.) · 2018Article
- Surgical approach in thymectomy: Our experience and review of the literature.International journal of surgery case reports · 2017Article
- Treatment of secondary hyperparathyroidism: the clinical utility of etelcalcetide.Therapeutics and clinical risk management · 2017Review
- Parathyroidectomy Associates with Reduced Mortality in Taiwanese Dialysis Patients with Hyperparathyroidism: Evidence for the Controversy of Current Guidelines.Scientific reports · 2016Article
- Pharmacogenetic analysis of cinacalcet response in secondary hyperparathyroidism patients.Drug design, development and therapy · 2016Article
- The Risk of Peripheral Arterial Disease after Parathyroidectomy in Patients with End-Stage Renal Disease.PloS one · 2016Article
- Surgical management of secondary hyperparathyroidism in chronic kidney disease--a consensus report of the European Society of Endocrine Surgeons.Langenbeck's archives of surgery · 2015Review
- The effect of parathyroidectomy on patient survival in secondary hyperparathyroidism.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2015Article
- Reduced Stroke Risk After Parathyroidectomy in End-Stage Renal Disease: A 13-Year Population-Based Cohort Study.Medicine · 2015Observational
- Application of total parathyroidectomy with auto-transplantation for uremia secondary hyperparathyroidism treatment.International journal of clinical and experimental medicine · 2015Article
- Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn chronic hemodialysis patients with secondary hyperparathyroidism, pathological modifications of bone and mineral metabolism increase the risk of cardiovascular morbidity and mortality. Parathyroidectomy, reducing the incidence of cardiovascular events, may improve outcomes; however, its effects on long-term survival are still subject of active research.
methodsFrom January 2004 to December 2006, 30 hemodialysis patients, affected by severe and unresponsive secondary hyperparathyroidism, underwent parathyroidectomy - 15 total parathyroidectomy and 15 total parathyroidectomy + subcutaneous autoimplantation. During a 5-year follow-up, patients did not receive a renal transplantation and were evaluated for biochemical modifications and major cardiovascular events - death, cardiovascular accidents, myocardial infarction and peripheral vascular disease. Results were compared with those obtained in a control group of 20 hemodialysis patients, affected by secondary hyperparathyroidism, and refusing surgical treatment, and following medical treatment only.
resultsThe groups were comparable in terms of age, gender, dialysis vintage, and comorbidities. Postoperative cardiovascular events were observed in 18/30 - 54% - surgical patients and in 4/20 - 20%- medical patients, with a mortality rate respectively of 23.3% in the surgical group vs. 15% in the control group. Parathyroidectomy was not associated with a reduced risk of cardiovascular morbidity and survival rate was unaffected by surgical treatment.
conclusionsIn secondary hyperparathyroidism hemodialysis patients affected by severe cardiovascular disease, surgery did not modify cardiovascular morbidity and mortality rates. Therefore, in secondary hyperparathyroidism hemodialysis patients, resistant to medical treatment, only an early indication to calcimimetics, or surgery, in the initial stage of chronic kidney disease - mineral bone disorders, may offer a higher long-term survival. Further studies will be useful to clarify the role of secondary hyperparathyroidism in determining unfavorable cardiovascular outcomes and mortality in hemodialysis population.
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