Evidence map›Paper›PMID 24267862›Full record

SynthesisThe British journal of general practice : the journal of the Royal College of General Practitioners2013

Association between point-of-care CRP testing and antibiotic prescribing in respiratory tract infections: a systematic review and meta-analysis of primary care studies.

Yafang Huang, Rui Chen, Tao Wu, Xiaoming Wei, Aimin Guo

Registry-linked trialOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The British journal of general practice : the journal of the Royal College of General Practitioners, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03540706 (Impact of the Use of C-reactive Protein in a Micro-method on the Prescription of Antibiotics in General Practitioners Consulting in the Office), which is not on this map. Cited by 66 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 9 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03540706 nacompletednot on this mapstarted 2018, after this paper: background citation

Impact of the Use of C-reactive Protein in a Micro-method on the Prescription of Antibiotics in General Practitioners Consulting in the Office

TypeinterventionalSponsorCentre Hospitalier Intercommunal CreteilRan2018 to 2023Enrolled406ConditionsRespiratory Infection, Respiratory Infections in ChildrenArmsCare with C-reactive protein assay in micro method
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 9 syntheses or guidelines pooled it, 128 citations in OpenAlex.

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  7. Antibiotic prescribing for acute respiratory tract infections in primary care: an updated and expanded meta-ethnography.The British journal of general practice : the journal of the Royal College of General Practitioners · 2018
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  14. Reducing inappropriate antibiotic prescribing for children in primary care: a cluster randomised controlled trial of two interventions.The British journal of general practice : the journal of the Royal College of General Practitioners · 2018
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yafang HuangSchool of General Practice and Continuing Education, Capital Medical University, Beijing, China.
Rui Chen
Tao Wu
Xiaoming Wei
Aimin Guo
Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMost patients with respiratory tract infections (RTIs) are prescribed antibiotics in general practice. However, there is little evidence that antibiotics bring any value to the treatment of most RTIs. Point-of-care C-reactive protein testing may reduce antibiotic prescribing.

aimTo systematically review studies that have examined the association between point-of-care (POC) C-reactive protein testing and antibiotic prescribing for RTIs in general practice. DESIGN AND

settingSystematic review and meta-analysis of randomised controlled trials and observational studies.

methodMEDLINE(®) and Embase were systematically searched to identify relevant publications. All studies that examined the association between POC C-reactive protein testing and antibiotic prescribing for patients with RTIs were included. Two authors independently screened the search results and extracted data from eligible studies. Dichotomous measures of outcomes were combined using risk ratios (RRs) with 95% confidence intervals (CIs) either by fixed or random-effect models.

resultsThirteen studies containing 10 005 patients met the inclusion criteria. POC C-reactive protein testing was associated with a significant reduction in antibiotic prescribing at the index consultation (RR 0.75, 95% CI = 0.67 to 0.83), but was not associated with antibiotic prescribing at any time during the 28-day follow-up period (RR 0.85, 95% CI = 0.70 to 1.01) or with patient satisfaction (RR 1.07, 95% CI = 0.98 to 1.17).

conclusionPOC C-reactive protein testing significantly reduced antibiotic prescribing at the index consultation for patients with RTIs. Further studies are needed to analyse the confounders that lead to the heterogeneity.

Indexed as

Point-of-Care SystemsAdultBiomarkersC-Reactive ProteinDrug PrescriptionsFemaleGeneral PracticeHumansMaleMiddle AgedObservational Studies as TopicPatient SatisfactionPhysician-Patient RelationsPractice Patterns, Physicians'Randomized Controlled Trials as TopicRespiratory Tract InfectionsBiomarkersC-Reactive Protein

Identifiers

PMID24267862
PMCPMC3809432
OpenAlexW2001955730

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.