ReviewBMC surgery2013
Health related quality of life in colorectal cancer patients: state of the art.
Review in BMC surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03832621 (NIVOLUMAB Plus IPILIMUMAB and TEMOZOLOMIDE in Combination in Microsatellite Stable), which is not on this map. Cited by 79 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NIVOLUMAB Plus IPILIMUMAB and TEMOZOLOMIDE in Combination in Microsatellite Stable (MSS), MGMT Silenced Metastatic Colorectal Cancer (mCRC): the MAYA Study
Who cites it
79 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Colorectal Cancer and Onset of Anxiety and Depression: A Systematic Review and Meta-Analysis.Current oncology (Toronto, Ont.) · 2022Pooled it
- A pair-wise meta-analysis highlights circular RNAs as potential biomarkers for colorectal cancer.BMC cancer · 2019Pooled it
- Prognostic factors for return to work and work disability among colorectal cancer survivors; A systematic review.PloS one · 2018Pooled it
- Candidate Predictors of Health-Related Quality of Life of Colorectal Cancer Survivors: A Systematic Review.The oncologist · 2016Pooled it
- Effects of Resistance Exercise on Quality of Life, Anxiety, Depression, Sleep Quality and Inflammatory Parameters in Patients with Colorectal Cancer Undergoing Active Treatment: A Pilot Randomized Clinical Trial.Current oncology (Toronto, Ont.) · 2025Trial
- The Effect of Vitamin D Supplementation on Quality of Life in Stage II-III Colorectal Cancer Patients Undergoing Adjuvant Chemotherapy: A Single-Blind, Randomized Controlled Trial.Journal of gastrointestinal cancer · 2024Trial
- Trial
- Trial
- Patient-reported symptom burden as a prognostic factor in treatment with first-line cetuximab plus chemotherapy for unresectable metastatic colorectal cancer: Results of Phase II QUACK trial.Cancer medicine · 2020Trial
- Trial
- Patient experiences and unmet needs in diagnosis and treatment of metastatic colorectal cancer: results of a US survey.Future oncology (London, England) · 2026Article
- Health-related quality of life and functional outcomes of colon cancer patients in the Netherlands: A population-based study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Observational
- Observational
- Health-Related Quality of Life in Patients with Colorectal Cancer: A Comparison Between Those With and Without Colostomy.Journal of caring sciences · 2025Review
- Investigating the Quality of Life and its Associated Factors in Patients with Colorectal Cancer.Advanced biomedical research · 2025Article
- Metformin Against Herpes Zoster in Colon Cancer Patients with Type 2 Diabetes: A PSM Analysis.Journal of Cancer · 2025Article
- Current Trends in the Biomarker's Discovery for the Treatment and Management of Colorectal Cancer: A Comprehensive Review.Current medicinal chemistry · 2025Review
- Specific Quality of Life Questionnaire Validation in Patients with Colorectal Cancer.Diagnostics (Basel, Switzerland) · 2024Article
- Clinically meaningful outcomes in refractory metastatic colorectal cancer: a decade of defining and raising the bar.ESMO open · 2024Review
- Assessing Preoperative (EORTC) QLQ-C30 Score in Elderly Patients with Colorectal Cancer: Results from a Prospective Cohort Study.Journal of clinical medicine · 2024Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColorectal cancer (CRC) is the third most commonly diagnosed cancer in males and the second in females with a progressive increase in prevalence in industrialized countries. The loss of health due to the cancer and/or the consequence of the treatment may result in psychophysical, functional and social impairment; all of these affect health-related quality of life (QoL). DESCRIPTION: The most frequently CRC-specific QoL questionnaires is the FACT-C. QoL is not only important for the well-being of cancer patient but it also influences survival and response to therapy. Many studies investigated various determinants involved in the assessment of QoL in CRC, suggesting that symptoms, surgical procedures and the number of comorbidity significantly affected QoL.
conclusionDespite that CRC patients have a relatively good QoL compared with the general population, a wide range of intervention could be undertaken to improve their QoL. The finding of this review may be useful for cancer clinicians in taking therapy and surveillance-related decisions. However, future research should be directed to large-scale prospective studies using well validated QoL instruments to facilitate comparison of results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.