ArticleCNS neuroscience & therapeutics2013
Platelet-derived microparticles are implicated in remote ischemia conditioning in a rat model of cerebral infarction.
Article in CNS neuroscience & therapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Preclinical evidence of remote ischemic conditioning in ischemic stroke, a metanalysis update.Scientific reports · 2021Pooled it
- Therapeutic potential of extracellular vesicles in preclinical stroke models: a systematic review and meta-analysis.BMJ open science · 2020Pooled it
- Effect of remote ischaemic conditioning on platelet reactivity and endogenous fibrinolysis in ST-elevation myocardial infarction: a substudy of the CONDI-2/ERIC-PPCI randomized controlled trial.Cardiovascular research · 2021Trial
- Platelet Extracellular Vesicles as Natural Delivery Vehicles for Mitochondrial Dysfunction Therapy?ACS biomaterials science & engineering · 2025Review
- A prospective cohort study on prognostic implications of serum platelet derived microparticles levels in acute cerebral infarction.Scientific reports · 2025Article
- Platelets, Protean Cells with All-Around Functions and Multifaceted Pharmacological Applications.International journal of molecular sciences · 2023Review
- Remote but not Distant: a Review on Experimental Models and Clinical Trials in Remote Ischemic Conditioning as Potential Therapy in Ischemic Stroke.Molecular neurobiology · 2022Review
- The antihypertensive effect of remote ischemic conditioning in spontaneously hypertensive rats.Frontiers in immunology · 2022Article
- Remote ischemic conditioning enhances oxygen supply to ischemic brain tissue in a mouse model of stroke: Role of elevated 2,3-biphosphoglycerate in erythrocytes.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Platelets as drivers of ischemia/reperfusion injury after stroke.Blood advances · 2021Review
- Diets and Cellular-Derived Microparticles: Weighing a Plausible Link With Cerebral Small Vessel Disease.Frontiers in cardiovascular medicine · 2021Review
- Immune Modulation as a Key Mechanism for the Protective Effects of Remote Ischemic Conditioning After Stroke.Frontiers in neurology · 2021Review
- Biology and Role of Extracellular Vesicles (EVs) in the Pathogenesis of Thrombosis.International journal of molecular sciences · 2019Review
- Washing or filtering of blood products does not improve outcome in a rat model of trauma and multiple transfusion.Transfusion · 2019Article
- Extracellular Vesicles in Angiogenesis.Circulation research · 2017Review
- Flow analysis of individual blood extracellular vesicles in acute coronary syndrome.Platelets · 2017Article
- Platelet-Derived Microvesicles in Cardiovascular Diseases.Frontiers in cardiovascular medicine · 2017Review
- Microvesicles in Atherosclerosis and Angiogenesis: From Bench to Bedside and Reverse.Frontiers in cardiovascular medicine · 2017Review
- Macrophage Foam Cell-Derived Extracellular Vesicles Promote Vascular Smooth Muscle Cell Migration and Adhesion.Journal of the American Heart Association · 2016Article
- Role of Platelet-Derived Microvesicles As Crosstalk Mediators in Atherothrombosis and Future Pharmacology Targets: A Link between Inflammation, Atherosclerosis, and Thrombosis.Frontiers in pharmacology · 2016Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimRemote ischemic preconditioning protects against ischemic organ damage by giving short periods of subcritical ischemia to a remote organ. We tested the hypothesis that remote ischemic conditioning can attenuate cerebral stroke in a rat middle cerebral artery occlusion (MCAO) model by microparticles (MPs). METHODS AND
resultsMPs were extracted from healthy rats that underwent hindlimb ischemia-reperfusion preconditioning (RIPC), and were transfused into rats that had undergone MCAO without RIPC. The transfusion resulted in an increase in platelet-derived MPs in blood and reduction in infarction area, confirmed by both 2-3-5-triphenyltetrazolium chloride staining and magnetic resonance imaging, albeit to a lesser degree than RIPC itself. Behavioral tests (modified Neurological Severity Score [mNSS]) were calculated to judge the behavioral change. However, no significant difference was observed after MP transfusion in 24 h or the following consecutive 9 days.
conclusionsRIPC induces an increase in MPs, and platelet-derived MPs may confer at least part of the remote protective effect against cerebral ischemic-reperfusion injury.
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