ArticleBMC surgery2013
Predictive value of nodal metastases on local recurrence in the management of differentiated thyroid cancer. Retrospective clinical study.
Article in BMC surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Skip metastases to lateral cervical lymph nodes in differentiated thyroid cancer: a systematic review.BMC surgery · 2019Pooled it
- Surgeon volume and hospital volume in endocrine neck surgery: how many procedures are needed for reaching a safety level and acceptable costs? A systematic narrative review.Il Giornale di chirurgiaPooled it
- Comparison of actual prognosis between unilateral and bilateral central neck dissection in modified radical neck dissection patients with no clinical central lymph node metastasis: a retrospective cohort study.Annals of surgical treatment and research · 2024Article
- A hybrid machine learning model combining association rule mining and classification algorithms to predict differentiated thyroid cancer recurrence.Frontiers in medicine · 2024Article
- Role of computed tomography in the evaluation of regional metastasis in well-differentiated thyroid cancer.Frontiers in radiology · 2023Article
- Risk factors for central lymph node metastasis in the cervical region in papillary thyroid carcinoma: a retrospective study.World journal of surgical oncology · 2021Article
- Medullary thyroid carcinoma with double negative calcitonin and CEA: a case report and update of literature review.BMC endocrine disorders · 2019Review
- Calcitonin negative Medullary Thyroid Carcinoma: a challenging diagnosis or a medical dilemma?BMC endocrine disorders · 2019Article
- The role of prophylactic central compartment lymph node dissection in elderly patients with differentiated thyroid cancer: a multicentric study.BMC surgery · 2019Article
- May predictors of difficulty in thyroid surgery increase the incidence of complications? Prospective study with the proposal of a preoperative score.BMC surgery · 2019Article
- Analysis of risk factors for cervical lymph node metastases in patients with sporadic medullary thyroid carcinoma.The Journal of international medical research · 2018Article
- Using Ultrasonography to Evaluate the Relationship between Capsular Invasion or Extracapsular Extension and Lymph Node Metastasis in Papillary Thyroid Carcinomas.Chinese medical journal · 2017Article
- An Approach to Macroscopic Central Lymph Nodes Detected during Surgery in Patients with Thyroid Micropapillary Carcinoma: Should We Resort to Dissection?International journal of endocrinology · 2017Article
- Article
- Role of prophylactic central compartment lymph node dissection in clinically N0 differentiated thyroid cancer patients: analysis of risk factors and review of modern trends.World journal of surgical oncology · 2016Review
- The relevance of preoperative ultrasound cervical mapping in patients with thyroid cancer.Canadian journal of surgery. Journal canadien de chirurgie · 2016Article
- Postoperative recurrence of papillary thyroid carcinoma with lymph node metastasis.Journal of surgical oncology · 2015Article
- Impact of prophylactic central neck dissection on oncologic outcomes of papillary thyroid carcinoma: a review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2015Review
- Conventional US, elastography, and contrast enhanced US features of papillary thyroid microcarcinoma predict central compartment lymph node metastases.Scientific reports · 2015Article
- Review
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11 authors at 3 institutions in 1 country.
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Abstract
backgroundThe significance of nodal metastases, very common in papillary thyroid cancer, and the role of lymph node dissection in the neoplasm management, are still controversial. The impact of lymph node involvement on local recurrence and long-term survival remains subject of active research. With the aim to better analyze the predictive value of lymph node involvement on recurrence and survival, we investigated the clinico-pathological patterns of local relapse following total thyroidectomy associated with lymph node dissection, for clinical nodal metastases papillary thyroid cancer, in order to identify the preferred surgical treatment.
methodsClinical records, between January 2000 and December 2006, of 69 patients undergoing total thyroidectomy associated with selective lymph node dissection for clinical nodal metastases papillary thyroid cancer, were retrospectively evaluated. Radioiodine ablation, followed by Thyroid Stimulating Hormone suppression therapy was recommended in every case. In patients with loco regional lymph nodal recurrence, a repeated lymph node dissection was carried out. The data were compared with those following total thyroidectomy not associated with lymph node dissection in 210 papillary thyroid cancer patients without lymph node involvement, at preoperative ultrasonography and intra operative inspection.
resultsIncidence of permanent hypoparathyroidism (iPTH < 10 pg/ml) and permanent monolateral vocal fold paralysis were respectively 1.4 % (1/69) and 1.4% (1/69), similar to those reported after total thyroidectomy "alone". The rate of loco regional recurrence, with positive cervical lymph nodes, following 8 year follow-up, was 34.7% (24/69), higher than that reported in patients without nodal metastases (4.2%). A repeated lymph node dissection was carried out without significant complications.
conclusionsNodal metastases are a predictor of local recurrence, and a higher rate of lymph node involvement is expected after therapeutic lymph node dissection associated with total thyroidectomy. The prognostic significance of nodal metastases on long-term survival remains unclear, and more prospective randomized trials are requested to better evaluate the benefits of different therapeutic approaches.
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