Evidence map›Paper›PMID 24267197›Full record

ReviewArthritis research & therapy2013

Use of NSAIDs in treating patients with arthritis.

Leslie J Crofford

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Arthritis research & therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 259 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
259citing papers in PubMed, 5 pooled it
16.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03771755 nacompletednot on this mapstarted 2017, after this paper: background citation

A Prospective, Randomized, Double-blind Study Assessing the Efficacy of Intravenous (IV) Ibuprofen Versus IV Acetaminophen for the Treatment of Pain Following Orthopaedic Low Extremity Surgery

TypeinterventionalSponsorIndonesia UniversityRan2017 to 2017Enrolled62ConditionsLower Extremity Problem, Surgery, Postoperative PainArmsIbuprofen, Acetaminophen
NCT07638189 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Pilot Study Using Topical Cannabidiol (CBD) to Manage Osteoarthritic Knee Pain

TypeinterventionalSponsorUniversity of TennesseeRan2026 to 2028Enrolled30ConditionsOsteoarthitisArmsCannabidiol (CBD), Castor Oil (Placebo)
3 · Its place in the literature

Who cites it

259 citing papers in PubMed, 5 syntheses or guidelines pooled it, 625 citations in OpenAlex.

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  4. Regenerative Therapies for Basal Thumb Arthritis-A Systematic Review.International journal of molecular sciences · 2023
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199 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Leslie J Crofford
Vanderbilt University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with rheumatic diseases, including rheumatoid arthritis and osteoarthritis, almost universally describe pain and stiffness as important contributors to reduced health-related quality of life. Of the treatment options available, NSAIDs are the most widely used agents for symptomatic treatment. NSAIDs are effective anti-inflammatory and analgesic drugs by virtue of their ability to inhibit biosynthesis of prostaglandins at the level of the cyclooxygenase enzyme. However, many of the adverse effects of NSAIDs are also related to inhibition of prostaglandin production, making their use problematic in some patient populations. For the clinician, understanding the biology of prostaglandin as it relates to gastrointestinal, renal, and cardiovascular physiology and the pharmacologic properties of specific NSAIDs is key to using these drugs safely. Of particular importance is the recognition of co-morbid conditions and concomitant drugs that may increase the risk of NSAIDs in particular patients. In patients with risk factors for NSAID toxicity, using the lowest dose of a drug with a short half-life only when it is needed is likely to be the safest treatment option. For those patients whose symptoms cannot be managed with intermittent treatment, using protective strategies is essential.

Indexed as

Anti-Inflammatory Agents, Non-SteroidalArthritisBiosynthetic PathwaysCardiovascular DiseasesHumansKidney DiseasesLiver DiseasesPainProstaglandinsRisk FactorsAnti-Inflammatory Agents, Non-SteroidalProstaglandins

Identifiers

PMID24267197
PMCPMC3891482
OpenAlexW1907909084

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.