ArticleBMC research notes2013
Nitrogen starvation-induced transcriptome alterations and influence of transcription regulator mutants in Mycobacterium smegmatis.
Article in BMC research notes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The PII protein interacts with the Amt ammonium transport and modulates nitrate/nitrite assimilation in mycobacteria.Frontiers in microbiology · 2024Article
- Mycobacterium smegmatis does not display functional redundancy in nitrate reductase enzymes.PloS one · 2021Article
- A recently evolved diflavin-containing monomeric nitrate reductase is responsible for highly efficient bacterial nitrate assimilation.The Journal of biological chemistry · 2020Article
- Nitrogen Regulator GlnR Controls Redox Sensing and Lipids Anabolism by Directly Activating theFrontiers in microbiology · 2019Article
- The Anti-mycobacterial Activity of a Diterpenoid-Like Molecule Operates Through Nitrogen and Amino Acid Starvation.Frontiers in microbiology · 2019Article
- The NnaR orphan response regulator is essential for the utilization of nitrate and nitrite as sole nitrogen sources in mycobacteria.Scientific reports · 2018Article
- The Synergistic Effect of Exogenous Glutamine and Rifampicin AgainstFrontiers in microbiology · 2018Article
- GlnR Activation Induces Peroxide Resistance in Mycobacterial Biofilms.Frontiers in microbiology · 2018Article
- Nitrogen regulator GlnR controls uptake and utilization of non-phosphotransferase-system carbon sources in actinomycetes.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Mycobacterium tuberculosis Is a Natural Ornithine Aminotransferase (rocD) Mutant and Depends on Rv2323c for Growth on Arginine.PloS one · 2015Article
- Nitrogen metabolism in Mycobacterium tuberculosis physiology and virulence.Nature reviews. Microbiology · 2014Review
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7 authors.
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Abstract
backgroundAs other bacteria, Mycobacterium smegmatis needs adaption mechanisms to cope with changing nitrogen sources and to survive situations of nitrogen starvation. In the study presented here, transcriptome analyses were used to characterize the response of the bacterium to nitrogen starvation and to elucidate the role of specific transcriptional regulators.
resultsIn response to nitrogen deprivation, a general starvation response is induced in M. smegmatis. This includes changes in the transcription of several hundred genes encoding e.g. transport proteins, proteins involved in nitrogen metabolism and regulation, energy generation and protein turnover. The specific nitrogen-related changes at the transcriptional level depend mainly on the presence of GlnR, while the AmtR protein controls only a small number of genes.
conclusionsM. smegmatis is able to metabolize a number of different nitrogen sources and nitrogen control in M. smegmatis is similar to control mechanisms characterized in streptomycetes, while the master regulator of nitrogen control in corynebacteria, AmtR, is plays a minor role in this regulatory network.
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