ArticleJournal of anatomy2014
Joint shape morphogenesis precedes cavitation of the developing hip joint.
Article in Journal of anatomy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- [Neurogenic hip dysplasia and hip dislocation : Pathophysiology, clinical presentation, and management in the context of cerebral palsy].Orthopadie (Heidelberg, Germany) · 2026Article
- Mechanical loading due to muscle movement regulates establishment of the collagen network in the developing murine skeleton.Royal Society open science · 2023Article
- Loss of Fgfr1 and Fgfr2 in Scleraxis-lineage cells leads to enlarged bone eminences and attachment cell death.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Local mechanical stimuli correlate with tissue growth in axolotl salamander joint morphogenesis.Proceedings. Biological sciences · 2022Article
- Human pluripotent stem cell-derived chondroprogenitors for cartilage tissue engineering.Cellular and molecular life sciences : CMLS · 2020Review
- Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity.Nature communications · 2020Article
- Development and growth of the pectoral girdle and fin skeleton in the extant coelacanth Latimeria chalumnae.Journal of anatomy · 2020Article
- Epiphyseal Cartilage Formation Involves Differential Dynamics of Various Cellular Populations During Embryogenesis.Frontiers in cell and developmental biology · 2020Article
- Prenatal growth map of the mouse knee joint by means of deformable registration technique.PloS one · 2019Article
- Morphogenetic mechanism of the acquisition of the dinosaur-type acetabulum.Royal Society open science · 2018Article
- Differential effects of altered patterns of movement and strain on joint cell behaviour and skeletal morphogenesis.Osteoarthritis and cartilage · 2016Article
- A Chick Embryo in-Vitro Model of Knee Morphogenesis.The archives of bone and joint surgery · 2016Article
- Phenotypical expression of reduced mobility during limb ontogeny in frogs: the knee-joint case.PeerJ · 2016Article
- Effects of normal and abnormal loading conditions on morphogenesis of the prenatal hip joint: application to hip dysplasia.Journal of biomechanics · 2015Article
- The importance of foetal movement for co-ordinated cartilage and bone development in utero : clinical consequences and potential for therapy.Bone & joint research · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biology and mechanobiology of joint cavitation have undergone extensive investigation, but we have almost no understanding of the development of joint shape. Joint morphogenesis, the development of shape, has been identified as the 'least understood aspect of joint formation' (2005, Birth Defects Res C Embryo Today 75, 237), despite the clinical relevance of shape morphogenesis to postnatal skeletal malformations such as developmental dysplasia of the hip. In this study, we characterise development of early hip joint shape in the embryonic chick using direct capture 3D imaging. Contrary to formerly held assumptions that cavitation precedes morphogenesis in joint development, we have found that the major anatomical features of the adult hip are present at Hamburger Hamilton (HH)32, a full day prior to cavitation of the joint at HH34. We also reveal that the pelvis undergoes significant changes in orientation with respect to the femur, despite the lack of a joint cavity between the rudiments. Furthermore, we have identified the appearance of the ischium and pubis several developmental stages earlier than was previously reported, illustrating the value and importance of direct capture 3D imaging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.