ReviewInfection & chemotherapy2013
The battle between influenza and the innate immune response in the human respiratory tract.
Review in Infection & chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19.Frontiers in public health · 2021Article
- Age-Dependent Glycomic Response to the 2009 Pandemic H1N1 Influenza Virus and Its Association with Disease Severity.Journal of proteome research · 2020Article
- Glycomic analysis of host response reveals high mannose as a key mediator of influenza severity.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Antiviral responses against chicken respiratory infections: Focus on avian influenza virus and infectious bronchitis virus.Cytokine · 2020Review
- Innate Immune Evasion by Human Respiratory RNA Viruses.Journal of innate immunity · 2020Review
- Immune responses in influenza A virus and human coronavirus infections: an ongoing battle between the virus and host.Current opinion in virology · 2018Review
- Postviral Complications: Bacterial Pneumonia.Clinics in chest medicine · 2017Review
- Article
- Hypothiocyanite produced by human and rat respiratory epithelial cells inactivates extracellular H1N2 influenza A virus.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Antiviral Activities of Several Oral Traditional Chinese Medicines against Influenza Viruses.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- TLR2 signaling decreases transmission of Streptococcus pneumoniae by limiting bacterial shedding in an infant mouse Influenza A co-infection model.PLoS pathogens · 2014Article
- How glycobiology can help us treat and beat the COVID-19 pandemic.The Journal of biological chemistryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Influenza is a viral infection of the respiratory tract. Infection is normally confined to the upper respiratory tract but certain viral strains have evolved the ability to infect the lower respiratory tract, including the alveoli, leading to inflammation and a disease pattern of diffuse alveolar damage. Factors leading to this sequence of events are novel influenza strains, or strains that have viral proteins, in particular the NS1 protein that allow it to escape the innate immune system. There are three main barriers that prevent infection of pneumocytes - mucin, host defence lectins and cells such as macrophages. Viruses have developed strategies such as neuraminidase and glycosylation patterns that allow this evasion. Though there has been much investment in antiviral drugs, it is proposed that more attention should be directed towards developing or utilizing compounds that enhance the ability of the innate immune system to combat viral infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.