ArticleEuropean journal of microbiology & immunology2013
Survey of extra-intestinal immune responses in asymptomatic long-term Campylobacter jejuni-infected mice.
Article in European journal of microbiology & immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 39 citations in OpenAlex.
- Oral curcumin ameliorates acute murine campylobacteriosis.Frontiers in immunology · 2024Article
- Human microbiota associated IL-10-/- mice: A valuable enterocolitis model to dissect the interactions of Campylobacter jejuni with host immunity and gut microbiota.European journal of microbiology & immunology · 2023Article
- Campylobacter jejuni infection induces acute enterocolitis in IL-10-/- mice pretreated with ampicillin plus sulbactam.European journal of microbiology & immunology · 2022Article
- Disease-Alleviating Effects of Peroral Activated Charcoal Treatment in Acute Murine Campylobacteriosis.Microorganisms · 2021Article
- Immune-Modulatory Effects upon Oral Application of Cumin-Essential-Oil to Mice Suffering from Acute Campylobacteriosis.Pathogens (Basel, Switzerland) · 2021Article
- Garlic Essential Oil as Promising Option for the Treatment of Acute Campylobacteriosis-Results from a Preclinical Placebo-Controlled Intervention Study.Microorganisms · 2021Article
- Peroral Clove Essential Oil Treatment Ameliorates Acute Campylobacteriosis-Results from a Preclinical Murine Intervention Study.Microorganisms · 2021Article
- Anti-Pathogenic and Immune-Modulatory Effects of Peroral Treatment with Cardamom Essential Oil in Acute Murine Campylobacteriosis.Microorganisms · 2021Article
- Preclinical Evaluation of Oral Urolithin-A for the Treatment of Acute Campylobacteriosis inPathogens (Basel, Switzerland) · 2020Article
- Toll-Like Receptor-4 Is Involved in Mediating Intestinal and Extra-Intestinal Inflammation inMicroorganisms · 2020Article
- Toll-Like Receptor-4 Dependent Intestinal and Systemic Sequelae Following PeroralPathogens (Basel, Switzerland) · 2020Article
- Vitamin C alleviates acute enterocolitis in Campylobacter jejuni infected mice.Scientific reports · 2020Article
- Carvacrol ameliorates acute campylobacteriosis in a clinical murine infection model.Gut pathogens · 2020Article
- Immunopathological properties of theGut pathogens · 2019Article
- Vitamin D in Acute Campylobacteriosis-Results From an Intervention Study Applying a ClinicalFrontiers in immunology · 2019Article
- Protease Activity ofFrontiers in cellular and infection microbiology · 2019Article
- Function of Serine Protease HtrA in the Lifecycle of the Foodborne PathogenEuropean journal of microbiology & immunology · 2018Review
- Multidrug-resistant Pseudomonas aeruginosa aggravates inflammatory responses in murine chronic colitis.Scientific reports · 2018Article
- Influence of the Gut Microbiota Composition on Campylobacter jejuni Colonization in Chickens.Infection and immunity · 2017Article
- Campylobacter jejuni and associated immune mechanisms: short-term effects and long-term implications for infants in low-income countries.Current opinion in infectious diseases · 2017Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Campylobacter jejuni is among the most frequently reported bacterial pathogens causing diarrhea in humans worldwide. We recently reported a murine infection model mimicking key features of human campylobacteriosis. Six days following oral C. jejuni infection immediately after weaning, infant mice developed acute enterocolitis resolving within 2 weeks. Thereafter, C. jejuni could still be isolated from the intestines of asymptomatic mice at low levels accompanied by distinct immune responses, both at intestinal and extra-intestinal locations. We here show that, at day 103 post infection (p.i.), long-term C. jejuni-infected mice exhibited higher numbers of T lymphocytes in liver, lung, kindneys, and cardiac muscle as compared to uninfected controls. In addition, B lymphocytes were slightly higher, but macrophage numbers were significantly lower in liver and lung of C. jejuni-infected versus naive mice. As compared to uninfected control animals, proliferating cells were significantly lower in liver, lung, kidneys, cardiac muscle, and spleen at day 103 p.i., whereas more apoptotic cells were abundant in the spleen with predominance in the red pulp. This study underlines that post-infectious, immunological sequelae at extra-intestinal locations are of importance even in asymptomatic long-term C. jejuni carriers and need to be further studied in order to unravel the underlying molecular mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.