ArticlePloS one2013
Drosophila UTX coordinates with p53 to regulate ku80 expression in response to DNA damage.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Independent signaling pathways provide a fail-safe mechanism to prevent tumorigenesis.bioRxiv : the preprint server for biology · 2025Article
- Double-strand breaks in facultative heterochromatin require specific movements and chromatin changes for efficient repair.Nature communications · 2024Article
- Article
- The Role of Histone Lysine Methylation in the Response of Mammalian Cells to Ionizing Radiation.Frontiers in genetics · 2021Review
- Histone demethylase UTX is a therapeutic target for diabetic kidney disease.The Journal of physiology · 2019Article
- UTX Mutations in Human Cancer.Cancer cell · 2019Review
- Inhibition of the Histone H3K27 Demethylase UTX Enhances Tumor Cell Radiosensitivity.Molecular cancer therapeutics · 2018Article
- Histone methylation in DNA repair and clinical practice: new findings during the past 5-years.Journal of Cancer · 2018Review
- p53 and cyclin G cooperate in mediating genome stability in somatic cells of Drosophila.Scientific reports · 2017Article
- Different expression patterns of histone H3K27 demethylases in renal cell carcinoma and bladder cancer.Cancer biomarkers : section A of Disease markers · 2017Article
- Review
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
UTX is known as a general factor that activates gene transcription during development. Here, we demonstrate an additional essential role of UTX in the DNA damage response, in which it upregulates the expression of ku80 in Drosophila, both in cultured cells and in third instar larvae. We further showed that UTX mediates the expression of ku80 by the demethylation of H3K27me3 at the ku80 promoter upon exposure to ionizing radiation (IR) in a p53-dependent manner. UTX interacts physically with p53, and both UTX and p53 are recruited to the ku80 promoter following IR exposure in an interdependent manner. In contrast, the loss of utx has little impact on the expression of ku70, mre11, hid and reaper, suggesting the specific regulation of ku80 expression by UTX. Thus, our findings further elucidate the molecular function of UTX.
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