SynthesisPloS one2013
Serum uric acid and chronic kidney disease: the role of hypertension.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Effects of uric acid-lowering therapy on the progression of chronic kidney disease: a systematic review and meta-analysis.Renal failure · 2018Pooled it
- [Full version of the S2e guidelines on gouty arthritis : Evidence-based guidelines of the German Society of Rheumatology (DGRh)].Zeitschrift fur Rheumatologie · 2016Guideline
- Serum uric acid is associated with incident chronic kidney disease in middle-aged populations: a meta-analysis of 15 cohort studies.PloS one · 2014Pooled it
- Development and Validation of Prediction Models for Hypertensive Nephropathy, the PANDORA Study.Frontiers in cardiovascular medicine · 2022Article
- Link between hyperuricemia, renal dysfunction, and hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- J-shaped Relationship Between Chronic Kidney Disease and Serum Uric Acid Levels: A Cross-sectional Study on the Korean Population.Journal of rheumatic diseases · 2021Article
- Association of uric acid and uric acid to creatinine ratio with chronic kidney disease in hypertensive patients.BMC nephrology · 2021Article
- Hyperuricemia and Hypertension, Coronary Artery Disease, Kidney Disease: From Concept to Practice.International journal of molecular sciences · 2020Review
- Baseline High Blood Pressure is Associated with Clinico-Pathologic Findings and Later Renal Progression in Chronic Glomerulonephritis.Electrolyte & blood pressure : E & BP · 2019Article
- Diet quality and chronic axonal polyneuropathy: a population-based study.Annals of clinical and translational neurology · 2019Article
- Asymptomatic hyperuricemia and cardiovascular mortality in patients with chronic kidney disease who progress to hemodialysis.International urology and nephrology · 2019Article
- Prevalence and treatment of gout among patients with chronic kidney disease in the Irish health system: A national study.PloS one · 2019Article
- Determinants of hyperuricemia in non-dialysed chronic kidney disease patients in three hospitals in Cameroon.BMC nephrology · 2018Article
- Association Between Uric Acid and Renal Hemodynamics: Pathophysiological Implications for Renal Damage in Hypertensive Patients.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Association Between Serum Uric Acid Levels/Hyperuricemia and Hypertension Among 85,286 Japanese Workers.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Uric acid is not associated with decline in renal function or time to renal replacement therapy initiation in a referred cohort of patients with Stage III, IV and V chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2015Article
- Uric Acid: A Missing Link Between Hypertensive Pregnancy Disorders and Future Cardiovascular Disease?Mayo Clinic proceedings · 2015Article
- Elevated uric acid level as a significant predictor of chronic kidney disease: a cohort study with repeated measurements.Journal of nephrology · 2015Article
- High uric acid level is a risk factor for progression of IgA nephropathy with chronic kidney disease stage G3a.Journal of nephrology · 2015Article
- Renal oxidative stress induced by long-term hyperuricemia alters mitochondrial function and maintains systemic hypertension.Oxidative medicine and cellular longevity · 2015Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are inconsistent findings on the role of hyperuricemia as an independent risk factor for chronic kidney disease (CKD). Hypertension has been implicated as a factor influencing the association between serum uric acid and CKD. In this population-based study we investigated the association between serum uric acid and decline in renal function and tested whether hypertension moderates this association.
methodsWe included 2601 subjects aged 55 years and over from the Rotterdam Study. Serum uric acid and estimated glomerular filtration rate (eGFR) were assessed at baseline. After average 6.5 years of follow-up, second eGFR was assessed. CKD was defined as eGFR<60 ml/min/1.73 m(2). All associations were corrected for socio-demographic and cardiovascular factors.
resultsEach unit (mg/dL) increase in serum uric acid was associated with 0.19 ml/min per 1.73 m(2) faster annual decline in eGFR. While the association between serum uric acid and incidence of CKD was not significant in our study population (Hazard Ratio: 1.12, 95% confidence interval [CI]: 0.98-1.28), incorporating our results in a meta-analysis with eleven published studies revealed a significant association (Relative Risk: 1.18, 95%CI: 1.15-1.22). In the stratified analyses, we observed that the associations of serum uric acid with eGFR decline and incident CKD were stronger in hypertensive subjects (P for interaction = 0.046 and 0.024, respectively).
conclusionsOur findings suggest that hyperuricemia is independently associated with a decline in renal function. Stronger association in hypertensive individuals may indicate that hypertension mediates the association between serum uric acid and CKD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.