ReviewFrontiers in microbiology2013
Mechanisms of pathogenesis induced by bovine leukemia virus as a model for human T-cell leukemia virus.
Review in Frontiers in microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
122 citing papers in PubMed, 1 synthesis or guideline pooled it, 222 citations in OpenAlex.
- Bovine leukemia virus relation to human breast cancer: Meta-analysis.Microbial pathogenesis · 2020Pooled it
- Combinations of long terminal repeat and tax protein substitutions influence bovine leukemia virus transmission through altered viral productivity.Microbiology spectrum · 2026Article
- Article
- Bovine Leukemia Virus as a One Health Challenge in Nutrition, Food Security, and Public Health: A Narrative Review.The Journal of nutrition · 2026Review
- Computational and Experimental Development of a Novel Multi-Epitope Vaccine Candidate Against Bovine Leukaemia Virus.Veterinary medicine and science · 2026Article
- Distribution and influence of single-nucleotide polymorphisms affecting bovine leukemia virus proviral load in semen and progeny derived from semen in Japanese Black cattle.The Journal of veterinary medical science · 2026Article
- Evaluation of bovine leukaemia virus infection control measures in Japanese Black beef cattle breeding farms: A 7-year longitudinal study based on proviral load.Veterinary record open · 2026Article
- Article
- Comparison of the Prevalence of Bovine Leukemia Virus (BLV) in Holstein and Angus Cattle Breeds From Shandong Province, China.Microbiology and immunology · 2026Article
- Engineered soluble truncated envelope proteins block bovine leukemia virus infection.Virus research · 2026Article
- Diversity of Integration Sites of Bovine Leukemia Virus (BLV) and Roles of Genes Related to Development of BLV-Induced Lymphoma in a Large Cohort.International journal of molecular sciences · 2026Article
- Integrated BLV surveillance in Kazakhstan, 2025: diagnostic complementarity and risk zoning.Frontiers in veterinary science · 2026Article
- Establishment and Characterization of Human Cell Lines Stably Infected With Bovine Leukemia Virus In Vitro Reveals Apoptosis After Latency and Silencing.Transboundary and emerging diseases · 2026Article
- First Evidence of Bovine Leukemia Virus in Culicoides Biting Midges and the Stable Fly Stomoxys calcitrans Collected on Cattle Farms in Poland.Transboundary and emerging diseases · 2026Article
- First Identification ofPathogens (Basel, Switzerland) · 2025Article
- Molecular epidemiology of bovine leukemia virus in cattle and phylogenetic analysis for determining its prevailing genotype in Khyber Pukhtunkhwa, Pakistan.Animal biotechnology · 2025Article
- Importance of continuous monitoring of bovine leukaemia virus infection on farms in bovine leukaemia virus-endemic areas of Japan.Veterinary record open · 2025Article
- Virological perspectives of the current situation of oncogenic viruses in Egypt: a review.Infectious agents and cancer · 2025Review
- Can Oncogenic Animal Viruses Pose a Threat to Humans?Pathogens (Basel, Switzerland) · 2025Review
- Identification of novel RNA polymerase III promoters in bovine leukemia virus miRNA cluster by cross-taxa analysis of small non-coding RNAs.BMC genomics · 2025Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine leukemia virus (BLV) and human T-cell leukemia virus type 1 (HTLV-1) make up a unique retrovirus family. Both viruses induce chronic lymphoproliferative diseases with BLV affecting the B-cell lineage and HTLV-1 affecting the T-cell lineage. The pathologies of BLV- and HTLV-induced infections are notably similar, with an absence of chronic viraemia and a long latency period. These viruses encode at least two regulatory proteins, namely, Tax and Rex, in the pX region located between the env gene and the 3' long terminal repeat. The Tax protein is a key contributor to the oncogenic potential of the virus, and is also the key protein involved in viral replication. However, BLV infection is not sufficient for leukemogenesis, and additional events such as gene mutations must take place. In this review, we first summarize the similarities between the two viruses in terms of genomic organization, virology, and pathology. We then describe the current knowledge of the BLV model, which may also be relevant for the understanding of leukemogenesis caused by HTLV-1. In addition, we address our improved understanding of Tax functions through the newly identified BLV Tax mutants, which have a substitution between amino acids 240 and 265.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.