ReviewFrontiers in pharmacology2013
Individual differences and the characterization of animal models of psychopathology: a strong challenge and a good opportunity.
Review in Frontiers in pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Multidimensional behavioral profiles associated with resilience and susceptibility after inescapable stress.Scientific reports · 2024Article
- Article
- Article
- Energizing effects of bupropion on effortful behaviors in mice under positive and negative test conditions: modulation of DARPP-32 phosphorylation patterns.Psychopharmacology · 2021Article
- Variability in Behavioral Phenotypes after Forced Swimming-Induced Stress in Rats Is Associated with Expression of the Glucocorticoid Receptor, Nurr1, and IL-1β in the Hippocampus.International journal of molecular sciences · 2021Article
- Male long-Evans rats: An outbred model of marked hypothalamic-pituitary-adrenal hyperactivity.Neurobiology of stress · 2021Article
- Incorporating inter-individual variability in experimental design improves the quality of results of animal experiments.PloS one · 2021Article
- Stress-Related Neuronal Clusters in Sublenticular Extended Amygdala of Basal Forebrain Show Individual Differences of Positions.Frontiers in neural circuits · 2020Article
- Decreased Density of Perineuronal Net in Prelimbic Cortex Is Linked to Depressive-Like Behavior in Young-Aged Rats.Frontiers in molecular neuroscience · 2020Article
- Reduced nucleus accumbens enkephalins underlie vulnerability to social defeat stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Preference for Exercise vs. More Sedentary Reinforcers: Validation of an Animal Model of Tetrabenazine-Induced Anergia.Frontiers in behavioral neuroscience · 2019Article
- The Utility of Rodent Models of Stress for Disentangling Individual Vulnerability to Depression and Cardiovascular Comorbidity.Current cardiology reports · 2018Review
- Plasma corticosterone, epinephrine, and norepinephrine levels increase during administration of nitrous oxide in rats.Stress (Amsterdam, Netherlands) · 2018Article
- Caffeine and Selective Adenosine Receptor Antagonists as New Therapeutic Tools for the Motivational Symptoms of Depression.Frontiers in pharmacology · 2018Review
- Estrous Cycle Phase-Dependent Changes in Anxiety- and Depression-Like Profiles in the Late Adolescent Wistar-Kyoto Rat.Annals of neurosciences · 2017Article
- Dysfunctional inhibitory mechanisms in locus coeruleus neurons of the wistar kyoto rat.The international journal of neuropsychopharmacology · 2015Article
- New frontiers in the neuropsychopharmacology of mental illness.Frontiers in pharmacology · 2014Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the development of valuable new techniques (i.e., genetics, neuroimage) for the study of the neurobiological substrate of psychiatric diseases, there are strong limitations in the information that can be gathered from human studies. It is thus critical to develop appropriate animal models of psychiatric diseases to characterize their putative biological bases and the development of new therapeutic strategies. The present review tries to offer a general perspective and several examples of how individual differences in animals can contribute to explain differential susceptibility to develop behavioral alterations, but also emphasizes methodological problems that can lead to inappropriate or over-simplistic interpretations. A critical analysis of the approaches currently used could contribute to obtain more reliable data and allow taking full advantage of new and sophisticated technologies. The discussion is mainly focused on anxiety-like and to a lower extent on depression-like behavior in rodents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.