ArticleFrontiers in computational neuroscience2013
Theoretical foundations of the sound analog membrane potential that underlies coincidence detection in the barn owl.
Article in Frontiers in computational neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Article
- Gamma frequency entrainment rescues cognitive impairment by decreasing postsynaptic transmission after traumatic brain injury.CNS neuroscience & therapeutics · 2023Article
- Robustness of neuronal tuning to binaural sound localization cues against age-related loss of inhibitory synaptic inputs.PLoS computational biology · 2021Article
- Theoretical Relationship Between Two Measures of Spike Synchrony: Correlation Index and Vector Strength.Frontiers in neuroscience · 2021Article
- Phase Locking of Auditory Nerve Fibers: The Role of Lowpass Filtering by Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Phase Locking of Auditory-Nerve Fibers Reveals Stereotyped Distortions and an Exponential Transfer Function with a Level-Dependent Slope.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Neural Maps of Interaural Time Difference in the American Alligator: A Stable Feature in Modern Archosaurs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Contribution of action potentials to the extracellular field potential in the nucleus laminaris of barn owl.Journal of neurophysiology · 2018Article
- Tonotopic Variation of the T-Type CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Physiological models of the lateral superior olive.PLoS computational biology · 2017Article
- A Test of the Stereausis Hypothesis for Sound Localization in Mammals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Neural Correlates of the Binaural Masking Level Difference in Human Frequency-Following Responses.Journal of the Association for Research in Otolaryngology : JARO · 2017Article
- Tonotopic Optimization for Temporal Processing in the Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Roles for Coincidence Detection in Coding Amplitude-Modulated Sounds.PLoS computational biology · 2016Article
- Article
- Biophysical basis of the sound analog membrane potential that underlies coincidence detection in the barn owl.Frontiers in computational neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
A wide variety of neurons encode temporal information via phase-locked spikes. In the avian auditory brainstem, neurons in the cochlear nucleus magnocellularis (NM) send phase-locked synaptic inputs to coincidence detector neurons in the nucleus laminaris (NL) that mediate sound localization. Previous modeling studies suggested that converging phase-locked synaptic inputs may give rise to a periodic oscillation in the membrane potential of their target neuron. Recent physiological recordings in vivo revealed that owl NL neurons changed their spike rates almost linearly with the amplitude of this oscillatory potential. The oscillatory potential was termed the sound analog potential, because of its resemblance to the waveform of the stimulus tone. The amplitude of the sound analog potential recorded in NL varied systematically with the interaural time difference (ITD), which is one of the most important cues for sound localization. In order to investigate the mechanisms underlying ITD computation in the NM-NL circuit, we provide detailed theoretical descriptions of how phase-locked inputs form oscillating membrane potentials. We derive analytical expressions that relate presynaptic, synaptic, and postsynaptic factors to the signal and noise components of the oscillation in both the synaptic conductance and the membrane potential. Numerical simulations demonstrate the validity of the theoretical formulations for the entire frequency ranges tested (1-8 kHz) and potential effects of higher harmonics on NL neurons with low best frequencies (<2 kHz).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.