ArticleBalkan journal of medical genetics : BJMG2013
Associations Between Variations in TPH1 , TPH2 and SLC6A4 Genes and Postpartum Depression: A Study in the Jordanian Population.
Article in Balkan journal of medical genetics : BJMG, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 5 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 5 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Identification of risk loci for postpartum depression in a genome-wide association study.Psychiatry and clinical neurosciences · 2024Pooled it
- Pooled it
- Perinatal Mental Illness in the Middle East and North Africa Region-A Systematic Overview.International journal of environmental research and public health · 2020Pooled it
- Human and economic resources for empowerment and pregnancy-related mental health in the Arab Middle East: a systematic review.Archives of women's mental health · 2019Pooled it
- Biological and psychosocial predictors of postpartum depression: systematic review and call for integration.Annual review of clinical psychology · 2015Pooled it
- Genetic, Epidemiological, and Clinical Risk Factors for Perinatal Anxiety and Depression in Dubai: Protocol for a 2-Point Prospective Observational Study.JMIR research protocols · 2025Observational
- Genetic Markers Associated with Postpartum Depression: A Review.Neuropsychiatric disease and treatment · 2024Review
- Comparative Analysis of Web of Science and Pubmed Indexed Medical Journals Published in Former Yugoslav Countries.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2020Article
- Reproductive Affective Disorders: a Review of the Genetic Evidence for Premenstrual Dysphoric Disorder and Postpartum Depression.Current psychiatry reports · 2017Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we investigated the association between tryptophan hydroxylase-1 (TPH1 ) (218A>C), tryptophan hydroxylase-2 ( TPH2 ) (1463G>A) and serotonin carrier family 6, member 4 (SLC6A4) [long (L) vs. short (S)] gene polymorphisms with post-partum depression (PPD) in women from Jordan. A total of 370 postpartum (130 depressed and 240 non depressed) women volunteered for the study. Genotyping was carried out using restriction fragment length polymorphism (RFLP) for TPH1 , amplification refractory mutation system (ARMS) for TPH2 and polymerase chain reaction (PCR) for SLC6A4 S and L. The Edinburgh postnatal depression scale was used to screen postpartum women. Both S and L alleles of SLC6A4 are common in Jordanian women (about 51.0 and 49.0%, respectively), while allele TPH1 -218C is more common (64.0%) than allele A (37.0%). Regarding TPH2 , allele A is absent from the examined women. None of the examined polymorphisms were found to be associated with PPD ( p >0.05). However, depression history, pregnancy problems and economic status were found to be significantly associated with PPD ( p <0.05). The results suggest that TPH1 , TPH2 and SLC6A4 S and L polymorphisms do not seem to be important in Jordan for predisposing to PPD.
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