ArticleMolecular vision2013
Measurement of tumor necrosis factor-alpha, interleukin-6, Fas ligand, interleukin-1α, and interleukin-1β in the aqueous humor of patients with open angle glaucoma using multiplex bead analysis.
Article in Molecular vision, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- The role of IL-6-174 G/C polymorphism and intraocular IL-6 levels in the pathogenesis of ocular diseases: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Citicoline and Coenzyme Q10: Therapeutic Agents for Glial Activation Reduction in Ocular Hypertension.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Multiple cytokine analysis of aqueous humor in uveitis with or without secondary glaucoma.BMC ophthalmology · 2024Article
- Article
- Nanoparticles for the treatment of glaucoma-associated neuroinflammation.Eye and vision (London, England) · 2022Review
- Contribution of Interleukin-17A to Retinal Degenerative Diseases.Frontiers in immunology · 2022Review
- Evaluating TNF-α and Interleukin-2 (IL-2) Levels in African American Primary Open-Angle Glaucoma Patients.Genes · 2021Article
- Neuroprotective role of epigallocatechin-3-gallate in acute glaucoma via the nuclear factor-κB signalling pathway.Experimental and therapeutic medicine · 2021Article
- Multiplex protein analysis for the study of glaucoma.Expert review of proteomics · 2021Review
- Retinal Molecular Changes Are Associated with Neuroinflammation and Loss of RGCs in an Experimental Model of Glaucoma.International journal of molecular sciences · 2021Article
- Time course of bilateral microglial activation in a mouse model of laser-induced glaucoma.Scientific reports · 2020Article
- Comparison of cytokine/chemokine levels in aqueous humor of primary open-angle glaucoma patients with positive or negative outcome following trabeculectomy.Bioscience reports · 2019Article
- Comparative analysis of cytokine profiles of glaucomatous tears and aqueous humour reveals potential biomarkers for trabeculectomy complications.FEBS open bio · 2019Article
- Is primary open-angle glaucoma an ocular manifestation of systemic disease?Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Review
- Inflammatory model in patients with primary open angle glaucoma and diabetes.International journal of ophthalmology · 2019Article
- Association of increased levels of plasma tumor necrosis factor alpha with primary open-angle glaucoma.Clinical ophthalmology (Auckland, N.Z.) · 2018Article
- Article
- Analyzing cytokines as biomarkers to evaluate severity of glaucoma.International journal of ophthalmology · 2017Article
- Cytokine biomarkers in tear film for primary open-angle glaucoma.Clinical ophthalmology (Auckland, N.Z.) · 2017Article
- Analysis of functional polymorphisms in apoptosis-related genes in primary open angle glaucoma.Molecular vision · 2015Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeVarious cytokines, including tumor necrosis factor-alpha (TNF-α), Fas ligand (FasL), interleukin-1α (IL-1α), interleukin-1β (IL-1β), and interleukin-6 (IL-6), contribute to the pathogenesis of primary open angle glaucoma (POAG). The present study was set to measure these cytokines in the aqueous humor of patients with POAG and in control subjects using multiplex bead analysis.
methodsTwenty-five patients with POAG and 29 control subjects were enrolled in this case-control study. Aqueous humor concentrations of the cytokines (IL-1 α, IL-1 β, IL-6, FasL, and TNF- α) were measured using multiplex bead analysis.
resultsMean aqueous humor levels of IL-6 were significantly lower in patients with POAG compared to the control subjects (9.3±23.7 versus 55.3±94.4 pg/ml; p=0.002). No significant difference in the aqueous humor concentration of IL-1β was found between patients with POAG and control subjects (0.5±0.8 versus 0.4±0.8 pg/ml; p=0.85.) Concentrations of IL-1α, TNF-α, and FasL were below limits of detection. No significant correlation was found between IL-6 concentration and age, duration of disease, cup/disc ratio, or mean deviation.
conclusionsIn the present study, we found significantly lower concentrations of IL-6 in the aqueous humor of patients with POAG.
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24265545PMC3834596W268153595What OpenQuestion holds
Registered trials
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