ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2014
Protective association between rotavirus vaccination and childhood seizures in the year following vaccination in US children.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 84 citations in OpenAlex.
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- Increased Risk of Neurological Disease Following Pediatric Rotavirus Infection: A Two-Center Case-Control Study.The Journal of infectious diseases · 2023Article
- Clinical characteristics, health care resource utilization and direct medical costs of Rotavirus hospitalizations in Spain (2013-2018).Human vaccines & immunotherapeutics · 2022Article
- Rotavirus infection-associated central nervous system complications: clinicoradiological features and potential mechanisms.Clinical and experimental pediatrics · 2022Article
- Association Between Rotavirus Vaccination and Antibiotic Prescribing Among Commercially Insured US Children, 2007-2018.Open forum infectious diseases · 2022Article
- Global Experience With Rotavirus Vaccines.The Journal of infectious diseases · 2021Article
- Paediatric rotavirus vaccination, coeliac disease and type 1 diabetes in children: a population-based cohort study.BMC medicine · 2021Article
- TIPICO X: report of the 10th interactive infectious disease workshop on infectious diseases and vaccines.Human vaccines & immunotherapeutics · 2021Article
- A Review of Febrile Seizures: Recent Advances in Understanding of Febrile Seizure Pathophysiology and Commonly Implicated Viral Triggers.Frontiers in pediatrics · 2021Review
- Rotavirus vaccination for all children or subgroups only? Comment of the European Academy of Paediatrics (EAP) and the European Society for Paediatric Infectious Diseases (ESPID) recommendation group for rotavirus vaccination.European journal of pediatrics · 2020Article
- Reduction in hospitalisations for acute gastroenteritis-associated childhood seizures since introduction of rotavirus vaccination: a time-series and change-point analysis of hospital admissions in England.Journal of epidemiology and community health · 2019Article
- Rotavirus infection beyond the gut.Infection and drug resistance · 2019Review
- Rotavirus Vaccination Is Associated With Reduced Seizure Hospitalization Risk Among Commercially Insured US Children.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Rotavirus vaccination and short-term risk of adverse events in US infants.Paediatric and perinatal epidemiology · 2018Article
- Safety study of live, oral human rotavirus vaccine: A cohort study in United States health insurance plans.Human vaccines & immunotherapeutics · 2018Article
- Lack of impact of rotavirus vaccines on seizure-related hospitalizations in children under 5 years old in Spain.Human vaccines & immunotherapeutics · 2018Article
- Report of the 5th European expert meeting on rotavirus vaccination (EEROVAC).Human vaccines & immunotherapeutics · 2018Article
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9 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundRotavirus illness has been linked to childhood seizures. We investigated whether a protective association exists between receipt of rotavirus vaccine and being hospitalized or visiting the emergency department for seizures in the year after vaccination.
methodsWe retrospectively analyzed a cohort of children born after 28 February 2006 (when rotavirus vaccine was licensed in the United States) and enrolled in the Vaccine Safety Datalink (VSD) through November 2009. Seizure rates from 4 to 55 weeks following last rotavirus vaccination were compared by vaccine exposure status (fully vaccinated and unvaccinated). A time-to-event analysis using a Cox proportional hazards model was performed, accounting for time-varying covariates. We calculated the relative incidence of seizure compared by vaccine exposure status during the postexposure interval.
resultsOur cohort contained VSD data on 250 601 infants, including 186 502 children fully vaccinated (74.4%) and 64 099 (25.6%) not vaccinated with rotavirus vaccine. Rates of seizures were associated with rotavirus vaccination status. After adjusting for covariates (VSD site, age at last dose, sex, and calendar month of the index date), a statistically significant protective association was observed between a full course of rotavirus vaccination vs no vaccination for both first-ever seizures (risk ratio [RR] = 0.82; 95% confidence interval [CI], .73-.91) and all seizures (RR = 0.79; 95% CI, .71-.88).
conclusionsA full course of rotavirus vaccination was statistically associated with an 18%-21% reduction in risk of seizure requiring hospitalization or emergency department care in the year following vaccination, compared with unvaccinated children. This reduction in childhood seizures complements the well-documented vaccine-related benefit of preventing US diarrhea hospitalizations.
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