ArticleParasitology research2014
Voriconazole as a first-line treatment against potentially pathogenic Acanthamoeba strains from Peru.
Article in Parasitology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- Voriconazole in the successful management of a case of Acanthamoeba-Cladosporium keratitis.American journal of ophthalmology case reports · 2021Article
- [Acanthamoeba endophthalmitis-a case report].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2020Article
- Antiamoebic activity of synthetic tetrazoles against Acanthamoeba castellanii belonging to T4 genotype and effects of conjugation with silver nanoparticles.Parasitology research · 2020Article
- Acanthamoeba Keratitis Associated with Scleral Contact Lens Use in a Keratoconus Patient.Beyoglu eye journal · 2020Article
- Outcomes of a Dispersive Ophthalmic Viscosurgical Device.Beyoglu eye journal · 2020Article
- Article
- Synthesis and in vitro activity of new biguanide-containing dendrimers on pathogenic isolates of Acanthamoeba polyphaga and Acanthamoeba griffini.Parasitology research · 2019Article
- Characterisation of sterol biosynthesis and validation of 14α-demethylase as a drug target in Acanthamoeba.Scientific reports · 2017Article
- Acanthamoeba genotypes T3 and T4 as causative agents of amoebic keratitis in Mexico.Parasitology research · 2016Article
- Statins and voriconazole induce programmed cell death in Acanthamoeba castellanii.Antimicrobial agents and chemotherapy · 2015Article
- Molecular cloning and expression of phosphoglycerate dehydrogenase and phosphoserine aminotransferase in the serine biosynthetic pathway from Acanthamoeba castellanii.Parasitology research · 2015Article
- Cysticidal activity of antifungals against different genotypes of Acanthamoeba.Antimicrobial agents and chemotherapy · 2014Article
- Cytotoxic effect of organic solvents and surfactant agents on Acanthamoeba castellanii cysts.Parasitology research · 2014Article
- Morphological Features and In Vitro Cytopathic Effect of Acanthamoeba griffini Trophozoites Isolated from a Clinical Case.Journal of parasitology research · 2014Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Pathogenic strains of Acanthamoeba genus are the causative agents of fatal granulomatous amoebic encephalitis and a serious sight-threatening infection of the eye known as Acanthamoeba keratitis. In a previous study, Acanthamoeba strains were isolated from nasal swabs collected from healthy individuals in Peru. In the present study, the pathogenic potential of the isolated strains was established based on temperature and osmotolerance assays as well as the secretion rate of extracellular proteases. Based on these experiments, four strains that showed the highest pathogenic potential were selected for sensitivity assays against two molecules (voriconazole and chlorhexidine) which are currently used for the treatment of Acanthamoeba infections. After performing sensitivity and activity assays, it was found that both drugs were active against the tested strains. However, voriconazole showed higher activity against the studied strains compared to chlorhexidine. Therefore, voriconazole should be established as a first-line treatment against Acanthamoeba infections at least in the studied region of Peru.
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