ReviewInternational urology and nephrology2014
Hypoxia and spermatogenesis.
Review in International urology and nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 63 citations in OpenAlex.
- Maternal hypoxia exposure perturbs imprinted gene methylation in adult sperm and induces intergenerational placental impairments in male offspring.Zoological research · 2025Article
- Ultrasonographic evaluation of testicular and Pampiniform plexus characteristics in young bulls under different microclimatic conditions in a tropical environment.Scientific reports · 2025Article
- The glucose metabolism reprogramming of yak Sertoli cells under hypoxia is regulated by autophagy.BMC genomics · 2025Article
- High-altitude hypoxia exposure alters follicular metabolome and oocyte developmental potential in women.Archives of gynecology and obstetrics · 2025Article
- Clinical evaluation and comprehensive management strategies for adolescent varicocele.Pediatric surgery international · 2025Review
- Research progress on the adverse effects of high-altitude environment to the male reproductive system: a review study.Frontiers in endocrinology · 2025Review
- Whole transcriptome sequencing revealed the gene regulatory network of hypoxic response in yak Sertoli cells.Scientific reports · 2024Article
- Review
- The role of HIF-1α-mediated autophagy in ionizing radiation-induced testicular injury.Journal of molecular histology · 2023Article
- Diabetes-Induced Autophagy Dysregulation Engenders Testicular Impairment via Oxidative Stress.Oxidative medicine and cellular longevity · 2023Article
- Factors predicting successful sperm retrieval in men with nonobstructive Azoospermia: A single center perspective.Health science reports · 2022Article
- Same total normal forms sperm counts of males from Lhasa and Shanghai, China.Environmental science and pollution research international · 2022Article
- Alterations of RNA Modification in Mouse Germ Cell-2 Spermatids Under Hypoxic Stress.Frontiers in molecular biosciences · 2022Article
- An integrative approach to uncover the components, mechanisms, and functions of traditional Chinese medicine prescriptions on male infertility.Frontiers in pharmacology · 2022Article
- Editorial: Intra- and extra-environment and reproduction.Frontiers in cell and developmental biology · 2022Article
- Heat shock protein-90alpha (Hsp90α) stabilizes hypoxia-inducible factor-1α (HIF-1α) in support of spermatogenesis and tumorigenesis.Cancer gene therapy · 2021Article
- Low oxygen tension potentiates proliferation and stemness but not multilineage differentiation of caprine male germline stem cells.Molecular biology reports · 2021Article
- Network pharmacology integrated molecular docking reveals the bioactive components and potential targets of Morinda officinalis-Lycium barbarum coupled-herbs against oligoasthenozoospermia.Scientific reports · 2021Article
- Cistanoside ofAmerican journal of translational research · 2021Article
- Impacts of Immunometabolism on Male Reproduction.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review mainly focuses on our understanding of spermatogenesis in physiological and pathological hypoxic condition. Real hypoxia is closely related to vascular changes and an increase in testicular temperature. Both induce a reduction in sperm count and can be related to the increase in germ cell apoptosis. On the other hand, change in the temperature, and oxygen levels in the microenvironment have influence on spermatogonial stem cell function and differentiation. The initial connection between hypoxia and a factor critical for stem cell maintenance is alteration in Oct-4 expression, and these data may be a useful strategy for modulating stem cell function. Unilateral testicular ischemia-induced cell death can be accompanied by an increase in germ cell apoptosis in the contralateral testis. The injury of contralateral testis following unilateral testicular damage is controversial, and it can contribute to the reduction in fertility.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.