Evidence map›Paper›PMID 24264961›Full record

ReviewJournal of thrombosis and thrombolysis2014

Small cells, big effects: the role of platelets in transplant vasculopathy.

Kristina L Modjeski, Craig N Morrell

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Journal of thrombosis and thrombolysis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03583229 (ECP Study), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03583229 naunknown statusnot on this mapstarted 2016, after this paper: background citation

ECP Study: Extracorporeal Photopheresis as Treatment of Cardiac Allograft Vasculopathy After Heart Transplantation and Evaluation of Platelet Function and Aggregation After Heart Transplantation

TypeinterventionalSponsorAarhus University HospitalRan2016 to 2021Enrolled70ConditionsCoronary Artery Disease in Transplanted Heart (Diagnosis), Platelet DysfunctionArmsAspirin 75mg, Extracorporeal photopheresis
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Testing the Efficacy of Contrast-Enhanced Ultrasound in Detecting Transplant Rejection Using a Murine Model of Heart Transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2017
    Article
  5. The incidence of aspirin resistance in heart transplantation recipients.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2017
    Article
  6. Article
  7. Novel mediators and biomarkers of thrombosis.Journal of thrombosis and thrombolysis · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kristina L ModjeskiAab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, ACVRI-211 Bailey Road, Rochester, NY, USA.
Craig N Morrell
University of Rochester · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platelets are the cellular mediator of thrombosis, but also represent an important part of the immune system. Platelets store numerous pre-formed inflammatory molecules in their granules and produce immune mediators de novo upon stimulation. Activated platelets express adhesion molecules that can interact with endothelial cells and leukocytes both at the site of inflammatory insult and in the circulation. Platelets therefore drive and potentiate vascular inflammation by direct and indirect interactions with both endothelial cells and leukocytes. Platelet activation has been associated with the pathogenesis of inflammatory diseases such as atherosclerosis, arthritis, and cerebral malaria, in addition to transplant vasculopathy. In this review we will discuss immune roles for platelets in the context of transplant vascular inflammation.

Indexed as

AnimalsBlood PlateletsEndothelium, VascularGraft RejectionHeart TransplantationHumansImmunity, CellularPlatelet ActivationVascular Diseases

Identifiers

PMID24264961
OpenAlexW2024682149

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.