ReviewCurrent rheumatology reports2014
HFE-related hemochromatosis: an update for the rheumatologist.
Review in Current rheumatology reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- [Chinese guidelines for the diagnosis and treatment of hereditary hemochromatosis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024Guideline
- Hepatic control of immunometabolism: implications for the pathogenesis, diagnosis and treatment of rheumatic diseases.Nature reviews. Rheumatology · 2026Review
- Osteoarthritis and analgesic consumption in haemochromatosis HFE C282Y homozygotes with normal or low iron parameters.Nature communications · 2026Article
- Chondrocalcinosis and the haemochromatosis-linkedEULAR rheumatology open · 2026Article
- Calcium Pyrophosphate Crystal Deposition: Insights to Risks Factors and Associated Conditions.Current rheumatology reports · 2024Review
- Hemochromatosis Genetic Variants and Musculoskeletal Outcomes: 11.5-Year Follow-Up in the UK Biobank Cohort Study.JBMR plus · 2023Article
- Nutritional Aspects of Iron in Health and Disease.Nutrients · 2023Review
- Analysis of Hand Joint Space Morphology in Women and Men with Hereditary Hemochromatosis.Calcified tissue international · 2023Article
- The effect of systemic iron status on osteoarthritis: A mendelian randomization study.Frontiers in genetics · 2023Article
- Hereditary haemochromatosis presenting to rheumatology clinic as inflammatory arthritis.BMJ case reports · 2022Article
- Iron Overload Induces Oxidative Stress, Cell Cycle Arrest and Apoptosis in Chondrocytes.Frontiers in cell and developmental biology · 2022Article
- Correlation of genotype and phenotype in 32 patients with hereditary hemochromatosis in China.Orphanet journal of rare diseases · 2021Article
- Iron triggers the early stages of cartilage degenerationOsteoarthritis and cartilage open · 2021Article
- Juvenile Hemochromatosis: Rheumatic Manifestations of 2 Sisters Responding to Deferasirox Treatment. A Case Series and Literature Review.Open access rheumatology : research and reviews · 2021Article
- Interplay Between Iron Overload and Osteoarthritis: Clinical Significance and Cellular Mechanisms.Frontiers in cell and developmental biology · 2021Review
- Bone and joint complications in patients with hereditary hemochromatosis: a cross-sectional study of 93 patients.Therapeutic advances in musculoskeletal disease · 2020Article
- Diagnosis and Treatment of GeneticGastroenterology research · 2019Review
- Hereditary Hemochromatosis Associations with Frailty, Sarcopenia and Chronic Pain: Evidence from 200,975 Older UK Biobank Participants.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- [Rheumatoid arthritis-mimics : When appearances are deceptive].Zeitschrift fur Rheumatologie · 2019Review
- Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK Biobank.BMJ (Clinical research ed.) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hereditary hemochromatosis is a frequent disease in Caucasian populations. It leads to progressive iron overload in a variety of organs. The most common cause is the C282Y homozygous mutation in the HFE gene. The classical triad of skin hyperpigmentation, diabetes, and liver cirrhosis is nowadays rare but musculoskeletal symptoms are common in HFE-related hemochromatosis. Typically the second and third metacarpophalangeal joints, and the wrist, hip, and ankle joints are affected. Clinical symptoms include osteoarthritis-like symptoms, pseudogout attacks, and synovitis sometimes resembling rheumatoid arthritis. Radiographs show degenerative changes with joint space narrowing, osteophytes, and subchondral cysts. Chondrocalcinosis in the wrist and knee joints is seen in up to 50 % of patients. Although most other organ manifestations regress during phlebotomy, musculoskeletal symptoms often persist or even become worse. Importantly, patients are at an increased risk of severe large-joint arthritis necessitating joint replacement surgery. Therefore, future research should focus on the pathogenesis and treatment options for HH arthropathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.