ArticleInflammation2014
Autophagy gene polymorphism is associated with susceptibility to leprosy by affecting inflammatory cytokines.
Article in Inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Functional single nucleotide polymorphisms in CACNA2D3 and other autophagy-related genes are associated with leprosy among Brazilians.PLoS neglected tropical diseases · 2026Article
- Leprosy: treatment, prevention, immune response and gene function.Frontiers in immunology · 2024Review
- Xenophagy as a Strategy forPathogens (Basel, Switzerland) · 2023Review
- Race-specific association of an IRGM risk allele with cytokine expression in human subjects.Scientific reports · 2023Article
- Differential Requirement for IRGM Proteins during Tuberculosis Infection in Mice.Infection and immunity · 2023Article
- Autophagopathies: from autophagy gene polymorphisms to precision medicine for human diseases.Autophagy · 2022Article
- Immunity-related GTPase IRGM at the intersection of autophagy, inflammation, and tumorigenesis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Review
- Targeting Autophagy as a Strategy for Developing New Vaccines and Host-Directed Therapeutics Against Mycobacteria.Frontiers in microbiology · 2020Review
- Advances in the Immunology and Genetics of Leprosy.Frontiers in immunology · 2020Review
- The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy.Molecular cell · 2019Article
- Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese.American journal of human genetics · 2018Article
- Mutagenic primer-based PCR-RFLP assay for genotyping IRGM gene promoter variant rs4958843 (C/T).Journal of clinical laboratory analysis · 2018Article
- Polymorphisms in Autophagy-Related GeneBioMed research international · 2018Article
- Article
- Innate Immune Responses in Leprosy.Frontiers in immunology · 2018Review
- LiveAmerican journal of translational research · 2018Article
- Identification of novel genetic loci GAL3ST4 and CHGB involved in susceptibility to leprosy.Scientific reports · 2017Article
- Autophagy Is an Innate Mechanism Associated with Leprosy Polarization.PLoS pathogens · 2017Article
- Sensing the enemy, containing the threat: cell-autonomous immunity to Chlamydia trachomatis.FEMS microbiology reviews · 2016Review
- The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease.Neuroscience · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autophagy and inflammation closely interact with each other, and together, they play critical roles in bacterial infection. Leprosy is caused by the infection of Mycobacterium leprae (M. leprae). The objective of the study was to investigate the association between polymorphisms in IRGM, an autophagy gene, and susceptibility to leprosy, and identify possible functions of the polymorphism in the infection of M. leprae. Two polymorphisms in IRGM, rs4958842 and rs13361189, were tested in 412 leprosy cases and 432 healthy controls. Levels of inflammatory cytokines including interleukin 1 beta, IL-4, IL-6, and interferon gamma (INF-γ) were measured after the infection of M. leprae in the peripheral blood mononuclear cell (PBMC) of subjects with different genotypes of rs13361189. Data showed that prevalence of rs13361189TC and CC genotypes were significantly higher in leprosy patients than in healthy controls (odds ratio (OR) = 1.49, 95 % confidence interval (CI) 1.09-2.04, P = 0.012; OR = 2.58, 95 % CI 1.65-4.05, P < 0.001; respectively). Furthermore, the frequency of rs13361189CC genotype was increased in patients with complications than those without complications (P = 0.011). When analyzing the effect of rs13361189 polymorphism on M. leprae infection, we identified that M. leprae-infected PBMC with rs13361189CC genotype expressed significantly elevated levels of INF-γ and IL-4 than those with TT genotype. Our results suggested autophagy gene polymorphism was associated with the increased risk of leprosy by affecting inflammatory cytokines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.