SynthesisClinical research in cardiology : official journal of the German Cardiac Society2014
The effect of placebo adherence on reducing cardiovascular mortality: a meta-analysis.
Synthesis in Clinical research in cardiology : official journal of the German Cardiac Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Investigating the role of acute mental stress on endothelial dysfunction: a systematic review and meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Pooled it
- Methylphenidate augmentation of escitalopram to enhance adherence to antidepressant treatment: a pilot randomized controlled trial.BMC psychiatry · 2021Trial
- A Multi-Framework Approach to Medication Adherence Evaluation in Pharmacy Student-Led Medication Reviews: An Observational Exploratory Study.Pharmacy (Basel, Switzerland) · 2026Article
- Is It All in Your Head? Placebo Effects in Concussion Prevention.Sports medicine (Auckland, N.Z.) · 2025Review
- Fixed-Dose Combination Formulations in Solid Oral Drug Therapy: Advantages, Limitations, and Design Features.Pharmaceutics · 2024Review
- Risk Factors Control After an Acute Coronary Syndrome and Association with Major Adverse Cardiovascular Events: A Single Center Experience in Latin-America.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2023Article
- Placebo: a brief updated review.Naunyn-Schmiedeberg's archives of pharmacology · 2022Review
- An Active Inference Approach to Dissecting Reasons for Nonadherence to Antidepressants.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Association of Statin Adherence With Mortality in Patients With Atherosclerotic Cardiovascular Disease.JAMA cardiology · 2019Article
- General practitioners' adherence to chronic heart failure guidelines regarding medication: the GP-HF study.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
- Analyses of drugs stored at home by elderly patients with chronic heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Article
- Does age modify the relationship between adherence to secondary prevention medications and mortality after acute myocardial infarction? A nested case-control study.European journal of clinical pharmacology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aim to demonstrate the effect of placebo adherence on reducing CV mortality. BACKGROUNDS: Good adherence, whether to drug or placebo treatment, is associated with lower CV mortality. However, current evidence for the positive effect of placebo adherence on reducing CV mortality is relatively weak.
methodsWe conducted a fixed-effect meta-analysis of eight randomized clinical trials to evaluate the effect of placebo adherence on reducing CV mortality. We made a comparison between good placebo adherence and poor drug adherence.
resultsCompared with poor adherence to drug treatment, good adherence to placebo treatment was associated with lower CV mortality (OR = 0.68, 95% CI 0.60-0.77).
conclusionGood adherence to placebo has a positive effect on reducing CV mortality. The effect of adherence on reducing CV mortality may be independent of the drug effect.
Indexed as
Identifiers
24264475What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.