Observational studyClinical research in cardiology : official journal of the German Cardiac Society2014
Impact of type 2 diabetes mellitus and glucose control on fractional flow reserve measurements in intermediate grade coronary lesions.
Observational study in Clinical research in cardiology : official journal of the German Cardiac Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Trial
- Diabetes does not impact the diagnostic performance of contrast-based fractional flow reserve: insights from the CONTRAST study.Cardiovascular diabetology · 2017Trial
- Comparison of Fractional Flow Reserve with Resting Non-Hyperemic Indices in Patients with Coronary Artery Disease.Journal of cardiovascular development and disease · 2023Article
- Influence of diabetes mellitus on the diagnostic performance of machine learning-based coronary CT angiography-derived fractional flow reserve: a multicenter study.European radiology · 2022Article
- Lesion Geometry as Assessed by Optical Coherence Tomography Is Related to Myocardial Ischemia as Determined by Cardiac Magnetic Resonance Imaging.Journal of clinical medicine · 2021Article
- Article
- Usefulness of Routine Fractional Flow Reserve for Clinical Management of Coronary Artery Disease in Patients With Diabetes.JAMA cardiology · 2020Article
- Predictors for target lesion microcalcifications in patients with stable coronary artery disease: an optical coherence tomography study.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Article
- Role of exercise cardiogoniometry in coronary artery disease diagnostics.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Article
- Comparison of standard- and high-dose intracoronary adenosine for the measurement of coronary fractional flow reserve (FFR).Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
- Clinical outcomes of deferred revascularisation using fractional flow reserve in patients with and without diabetes mellitus.Cardiovascular diabetology · 2016Article
- Detection of coronary artery disease in postmenopausal women: the significance of integrated stress imaging tests in a 4-year prognostic study.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Article
- Role of coronary physiology in the contemporary management of coronary artery disease.World journal of clinical cases · 2015Review
- Correlation between optical coherence tomography-derived intraluminal parameters and fractional flow reserve measurements in intermediate grade coronary lesions: a comparison between diabetic and non-diabetic patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHemodynamic relevance of intermediate grade coronary stenoses is accurately assessed by fractional flow reserve (FFR) measurements. However, the reliability of FFR in patients with type 2 diabetes mellitus (DM) and inadequate glucose control (IGC) is incompletely explored. This study aimed to investigate the impact of DM and IGC on the relationship between FFR measurements and quantitative coronary angiography (QCA)-derived morphological parameters.
methodsWe performed FFR and QCA in 266 intermediate grade lesions of 224 patients (113 non-DM and 111 DM) with stable coronary artery disease. Diabetic patients were categorized into groups with adequate (HbA1C <7%) and inadequate (HbA1c ≥7%) glucose control.
resultsIntermediate grade lesions from all-DM versus non-DM patients differed significantly in lesion length (LL) (10.91 ± 5.79 mm versus 9.23 ± 3.85 mm, p = 0.005) and hemodynamic relevance (FFR ≤0.8, 37.7% versus 24.2%, p = 0.018). FFR measurements in non-DM, all-DM and DM-IGC patients correlated significantly with percent diameter stenosis (%DS) [non-DM: r2 = 0.075 (p = 0.007); all-DM: r2 = 0.254 (p < 0.001), DM-IGC: r2 = 0.301 (p < 0.001)] and LL [non-DM: r2 = 0.356; all-DM: r2 = 0.580, DM-IGC: r2 = 0.513 (all p < 0.001)]. There was a better correlation between FFR and both %DS (p = 0.022) and LL (p = 0.011) among all-DM compared to non-DM patients. Receiver-operating curve analysis demonstrated that among all QCA-derived parameters LL had the best diagnostic efficacy to predict FFR ≤0.8 for non-DM (AUC 0.911, 95% CI 0.861-0.960, best cut-off value 9.22 mm), all-DM (AUC 0.967, 95% CI 0.942-0.991, best cut-off value 9.97 mm) and DM-IGC (AUC 0.960, 95% CI 0.920-0.999, best cut-off value 9.97 mm) patients.
conclusionOur data in intermediate grade lesions suggest that FFR is reliable in DM patients and LL is the best predictor for hemodynamic relevance in patients without and with diabetes, irrespective of the glycemic state.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.