Trial reportNutrients2013
Oats in the diet of children with celiac disease: preliminary results of a double-blind, randomized, placebo-controlled multicenter Italian study.
Trial report in Nutrients, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02612766 (SAFETY AND TOLERABILITY OF OAT CONTAINING GLUTEN-FREE DIET), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety and tolerability of oat containing gluten-free diet
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A case for improved assessment of gut permeability: a meta-analysis quantifying the lactulose:mannitol ratio in coeliac and Crohn's disease.BMC gastroenterology · 2022Pooled it
- Trial
- Gluten Contamination of Labelled Gluten-Free Food Products Marketed in China.Foods (Basel, Switzerland) · 2025Article
- Oats as a Safe Alternative to Triticeae Cereals for People Suffering from Celiac Disease? A Review.Plant foods for human nutrition (Dordrecht, Netherlands) · 2020Review
- To Be Oats or Not to Be? An Update on the Ongoing Debate on Oats for Patients With Celiac Disease.Frontiers in pediatrics · 2019Review
- Diagnostic accuracy of blood sucrose as a screening test for equine gastric ulcer syndrome (EGUS) in weanling foals.Acta veterinaria Scandinavica · 2018Article
- Gluten-Free Products for Celiac Susceptible People.Frontiers in nutrition · 2018Review
- The Long-Term Consumption of Oats in Celiac Disease Patients Is Safe: A Large Cross-Sectional Study.Nutrients · 2017Article
- Perspective: Gluten-Free Products for Patients with Celiac Disease Should Not Contain Trace Levels.Advances in nutrition (Bethesda, Md.) · 2017Article
- Pediatric Celiac Disease: Follow-Up in the Spotlight.Advances in nutrition (Bethesda, Md.) · 2017Review
- Characterization of celiac disease related oat proteins: bases for the development of high quality oat varieties suitable for celiac patients.Scientific reports · 2017Article
- Gluten Contamination in Naturally or Labeled Gluten-Free Products Marketed in Italy.Nutrients · 2017Article
- Properties of Gluten Intolerance: Gluten Structure, Evolution, Pathogenicity and Detoxification Capabilities.Nutrients · 2016Review
- Pure Oats as Part of the Canadian Gluten-Free Diet in Celiac Disease: The Need to Revisit the Issue.Canadian journal of gastroenterology & hepatology · 2016Review
- Celiac Disease and Gluten-Free Oats: A Canadian Position Based on a Literature Review.Canadian journal of gastroenterology & hepatology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A gluten-free diet (GFD) is currently the only available treatment for patients with celiac disease (CD). Several clinical trials have demonstrated that most celiac patients can tolerate a medium-high quantity of oats without any negative clinical effects; however, the inclusion of oats in GFD is still a matter of debate. In this study, Italian children with CD were enrolled in a 15-month, randomized, double-blind, placebo-controlled multicenter trial. Participants were randomized in two groups following either A-B treatment (6 months of diet "A", 3 months of standard GFD, 6 months of diet "B"), or B-A treatment (6 months of diet "B", 3 months of standard GFD, 6 months of diet "A"). A and B diets included gluten-free (GF) products (flour, pasta, biscuits, cakes and crisp toasts) with either purified oats or placebo. Clinical data (Gastrointestinal Symptoms Rate Scale [GSRS] score) and intestinal permeability tests (IPT), were measured through the study period. Although the study is still blinded, no significant differences were found in GSRS score or the urinary lactulose/mannitol (L/M) ratio between the two groups after 6 months of treatment. These preliminary results suggest that the addition of non-contaminated oats from selected varieties in the treatment of children with CD does not determine changes in intestinal permeability and gastrointestinal symptoms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.