ArticleInternational journal of legal medicine2014
A time-course analysis of mRNA expression during injury healing in human dermal injuries.
Article in International journal of legal medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- State-of-the-Art on Wound Vitality Evaluation: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Review of the current and potential use of biological and molecular methods for the estimation of the postmortem interval in animals and humans.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2023Review
- The molecular mechanisms supporting the homeostasis and activation of dendritic epidermal T cell and its role in promoting wound healing.Burns & trauma · 2021Review
- Temporal expression of wound healing-related genes inform wound age estimation in rats after a skeletal muscle contusion: a multivariate statistical model analysis.International journal of legal medicine · 2020Article
- RNU6B, a frequent reference in miRNA expression studies, differentiates between deaths caused by hypothermia and chronic cardiac ischemia.International journal of legal medicine · 2020Article
- Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors.American journal of human genetics · 2017Article
- Potential implications of interleukin-7 in chronic wound healing.Experimental and therapeutic medicine · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The determination of dermal injury age is important in forensic practice. It helps answer questions that are important to an investigation such as the timing of the injury and incident, the order of infliction (where there is more than one injury), the survival time after injury (post-infliction interval) and the relation of the injury to the incident. Despite the importance of injury age determination, there currently exists no reliable method to estimate dermal injury age. In this study, the expression of the following 14 mRNAs was studied in human dermal injuries and their usefulness in the estimation of human dermal injury age was evaluated: dual specificity phosphate 1 (DUSP1), interleukin 7 (IL7), vascular cell adhesion molecule 1, tenascin C, cluster of differentiation 14, interleukin 6, tumour necrosis factor alpha (TNFα), interleukin 1beta (IL1β), chymase 1 (CMA1), collagen type III alpha I, interleukin 2, collagen type I alpha I, collagen type I alpha II and vascular endothelial growth factor A (VEGFA). DUSP1, IL7, TNFα and VEGFA showed an initial decrease in expression during the early stages followed by an increase in expression towards the middle and late phases. IL1β and CMA1 expression was limited to specific time points. The remaining markers either showed inconsistent expression or were undetected in our samples. The expression patterns of the detected markers suggest they have potential to predict injury age, especially during the initial stages of injury healing, if used in combination with one another.
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